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茶多酚对人结肠癌细胞株Caco-2细胞凋亡及细胞周期的影响 被引量:5

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摘要 目的探讨茶多酚对人结肠癌细胞株Caco-2细胞凋亡及细胞周期的影响。方法体外培养Caco-2细胞,采用不同浓度(0、12.5、25、50、100μmol/L)的茶多酚对其进行干预,MTT法检测Caco-2细胞增殖抑制率,流式细胞仪检测Caco-2细胞凋亡率及细胞周期的变化。结果茶多酚能抑制Caco-2细胞增殖,且呈剂量依赖性;茶多酚能诱导Caco-2细胞凋亡,且呈剂量依赖性;茶多酚能将Caco-2细胞周期阻滞在G0/G1期。结论茶多酚对体外培养的Caco-2细胞的增殖有明显抑制作用,且能诱导细胞凋亡和影响细胞周期。
出处 《广东医学》 CAS 北大核心 2015年第1期50-52,共3页 Guangdong Medical Journal
基金 2011年度三峡大学科学基金项目(第二批)(编号:KJ2011A021)
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