防惊汤对热性惊厥大鼠惊厥复发的影响

Impact of Fangjing Decoction on Recurrence of Febrile Convulsion in Rats

目的观察防惊汤对热性惊厥大鼠惊厥复发的作用。方法筛选24只热性惊厥大鼠随机分为模型组、中药组、苯巴比妥组,每组8只。模型组给予生理盐水8 ml/(kg·d)灌胃,苯巴比妥组给予苯巴比妥10 mg/(kg·d)灌胃,中药组给予防惊汤6 g/(kg·d)灌胃,各组均连续灌胃7天。从第8天开始,对各组大鼠连续5天在灌胃后进行47℃热水浴试验,每天惊厥1次,共惊厥5次,观察大鼠发生惊厥的潜伏期、发作持续时间、惊厥程度以及惊厥发作时大鼠的肛温。结果与模型组比较,中药组及苯巴比妥组大鼠惊厥潜伏期延长,惊厥持续时间均减少,发作程度较轻(P<0.05)。各组大鼠惊厥发作时肛温均大于43℃,超过温度计的测试范围。结论防惊汤能延长热性惊厥大鼠惊厥复发的潜伏期、缩短惊厥持续时间、减轻惊厥发作程度。

Objective To observe the effect of Fangjing Decoction on recurrence of febrile convulsion in rats.Methods In total 24 rats with febrile convulsion were screened and randomly divided into model group,TCM group,and phenobarbital group,with 8 in each. The model group was treated with 8 ml /（ kg·d） of normal saline by gavage,while the phenobarbital group with 10 mg /（ kg·d） of phenobarbital and TCM group with 6 g /（ kg·d） of raw medicinals of Fangjing Decoction,all for 7 days. From day 8,all rats underwent 47℃ hot water bath test after gavage to induce febrile convulsion once daily for five consecutive days. The latency,duration and severity of the convulsions were observed and rectal temperature was measured. Results The latency of convulsions was longer,the duration was shortened,and the severity was less in the TCM group and phenobarbital group than that in the model group（ P〈0. 05）. The rectal temperature of all rats were higher than 43℃ during convulsions,which exceeded the test range of the thermometer. Conclusion Fangjing Decoction could prolong the latency of recurrence of febrile convulsions,shorten duration and lessen the degree of convulsions.