摘要
利用林生毛霉对16,17α-环氧黄体酮进行生物转化,得到两个转化产物。利用IR、MS、2D NMR等波谱方法检测化合物结构,确证其分别为7α-羟基-16,17α-环氧黄体酮(2)和7α,20β-二羟基-16,17α-环氧黄体酮(3)。林生毛霉对16,17α-环氧黄体酮的羟基化作用主要发生在C-7α位。通过DEPT和1H-1H COSY,HSQC,HMBC等2D NMR技术对产物13C NMR数据进行了全归属,详细地解析了产物3的结构。
The microbial transformation of 16, 17α -epoxyprogesterone by the fungus Mucor silvctticus afforded two metabolites, 7α - hydroxy - 16,17α - epoxyprogesterone （2） and 7α,2013 - dihydroxy - 16,17α - epoxyprogesterone （ 3 ）. The structure elucidation of the products was achieved by IR, MS and 2D NMR. It appears that the fungus predominantly hydroxylated at the 7α position. The complete assignments of 13C NMR chemical shifts of these compounds were obtained by 2D NMR techniques including DEPT, 1H -1H COSY, HSQC, HMBC. The spectroscopic analysis of compound 3 was discussed in detail.
出处
《山东化工》
CAS
2015年第3期12-16,共5页
Shandong Chemical Industry
基金
校硕士启动基金(S2006-9)
