止咳散加味治疗外感后慢性咳嗽55例的临床疗效分析

A clinical analysis of treating 55 cases of chronic cough after exogenous with Zhike San

目的:观察止咳散加味治疗外感后慢性咳嗽的临床疗效,为临床疗效提供参考。方法:将符合入组标准的110例外感后慢性咳嗽患者随机分为观察组55例和对照组55例,对照组进行常规方法治疗,包括化痰止咳抗炎药物及抗生素等,观察组在对照组的基础上再给予止咳散加味治疗,两组均治疗7d,治疗前后观察咳嗽及胸部X线改善情况,记录咳嗽消失时间,进行日间、夜间咳嗽评分,评价两组临床疗效及中医症候疗效。结果:1观察组和对照组治疗后日间、夜间咳嗽积分明显小于治疗前,差异具有统计学意义(均P<0.05),观察组治疗后日间、夜间咳嗽积分明显小于对照组,差异具有统计学意义(均P<0.05)。2观察组治疗7d后咳嗽消失率明显高于对照组,差异具有统计学意义(x2=13.046,P<0.05),咳嗽消失时间明显短于对照组。3观察组临床总疗效、中医症候疗效明显高于对照组,差异具有统计学意义(x2=16.320和14.790,均P<0.05)。结论:止咳散加味治疗外感后慢性咳嗽的临床疗效确切,更好、更快地改善咳嗽等症状体征,提高临床疗效及中医症候疗效,且安全性良好,是治疗外感后慢性咳嗽的简便廉验、安全有效的治疗方法,值得临床推广使用。

Objective： To observe clinical effects of Zhike San on chronic cough after exogenous, and provide reference for clinic application. Methods： 110 patients were randomly divided into two groups, 55 cases for each. The control was given the routine treatment as Huatan Zhike medicine, anti-inflammatory drugs and antibiotics; while the observation was given Zhike San more. Cough and chest X-ray situation were observed before and after treatment, disapppeared time of cough in two groups was recorded and compared. Results： I. In two groups, cough scores in day and night were obviously less than before, the difference was statistically significant （P〈0.05）, the score in the observation was less than that in the control, the difference was statistically significant （P〈0.05）. II. In 7 days, disappearance rate of cough in the observation was obviously higher than the control, the difference was statistically significant （x^2=13.046, P〈0.05）, the same as the disappered time of cough. III.The total effect and the efficacy of TCM symptoms in the observation were higher, with statistically significant difference （x^2=16.320 and 14.790, P〈0.05）. Conclusion： Zhike San has confirmed effects, can improve symptoms better and quicker, improve clinical effects with safety. All proved that it was a simple and effective method, and was worthy of application.