不同方案治疗术后腹膜后恶性淋巴结转移癌的疗效对比

Comparative Analysis on Clinical Efficacy of Different Treatment for Postoperative Malignant Retroperitoneal Lymph Node Metastasis Carcinoma

目的:比较不同方案治疗术后腹膜后恶性淋巴结转移癌的临床疗效差异。方法:选取本院收治的58例消化道恶性肿瘤术后发生腹膜后恶性淋巴结转移癌的患者,分为对照组(FOLFOX4方案单纯化疗)和观察组(三维适形放疗同步FOLFOX4方案),比较两组肿瘤控制率、KPS评分、不良反应发生率和远期生存率的差异。结果:观察组肿瘤控制率为82.8%,显著高于对照组的62.1%,观察组KPS评分显著高于对照组,观察组累积生存率和平均生存期均显著高于对照组,比较差异有统计学意义(P<0.05);两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论:三维适形放疗同步FOLFOX4方案治疗术后腹膜后恶性淋巴结转移癌效果确切,有利于肿瘤的控制,近远期疗效均好。

Objective： To compare clinical efficacy of different treatment for postoperative malignant retroperitoneal lymph node metastasis carcinoma. Method： 58 cases with retroperitoneal lymph node metastases after resection of gastrointestinal cancer surgery in our hospital were randomly divided into control group （ treated with FOLFOX4 ） and observation group （ treated with three-dimensional conformal radiotherapy synchronous FOLFOX4 ） . The tumor control rate, KPS score, adverse reactions rate and long-term survival rate of two groups were compared. Result： Tumor control rate of observation group was 82.8%, which was significantly higher than 62.1% of the control group （ P〈0.05 ） . KPS score of observation group was significantly higher than that of the control group （ P〈0.05 ） . Adverse reactions rate of the two groups had no significant difference （ P〉0.05 ） . Cumulative survival rate and mean survival time of observation group were significantly higher than that of the control group （ P〈0.05 ） . Conclusion： Three-dimensional conformal radiotherapy synchronous FOLFOX4 for postoperative malignant retroperitoneal lymph node metastasis carcinoma has exact effect with a high near-term effect. It＇s conducive to tumor control.