卡介苗多糖核酸联合复方甘草酸苷治疗慢性湿疹疗效观察

Therapeutic efficacy of the treatment to chronic eczema by BCG-PSN combined with compound Glycyrrhizin

目的:研究卡介苗多糖核酸联合复方甘草酸苷治疗慢性湿疹疗效。方法:将153例慢性湿疹患者随机分为两组,对照组(n=77)予口服复方甘草酸苷50 mg,3次·d-1,局部外用哈西奈德软膏,每天2次;治疗组(n=76)在对照组用药基础上加用卡介苗多糖核酸0.70 mg,隔日1次,肌肉注射;总疗程为3个月,分别于治疗1、2、3个月后评估疗效并记录不良反应。结果:第2个、第3个月末治疗组的有效率(分别为68.42%、85.53%)均明显高于对照组(分别为51.95%、70.13%),两组间差异有统计学意义(P<0.05),治疗过程中无明显不良反应。结论:在常规治疗基础上,加用卡介苗多糖核酸联合复方甘草酸苷治疗慢性湿疹疗效满意,安全可靠,值得临床推广应用。

Objective： To observe the clinical efficacy of the treatment to chronic eczema by bacillus calmetteguerin polysaccharide nucleic acid （BCG-PSN） combined with compound Glycyrrhizin. Methods： One hundred and fifty-three patients with chronic eczema were randomly divided into two groups, 77 patients in control group were treated with oral compound glycyrrhizin 50 mg,3 times a day, halcinonide ointment for external use ,2 times a day. On the basis of control group,76 patients in treatment group were treated with intramuscular BCG-PSN, 0. 70 mg, every other day in addition. The total course of treatment was 3 months, and then evaluate the efficacy and record the adverse reactions at the end of month 1,2 and 3. Results： Two, three months after treatment , the total effective rate of treatment group （68.42% and 85.53% ,respectively） were significantly higher than those of the control group （51.95 % and 70. 13 %, respectively）. The differences were statistically significant （ P 〈 0. 05 ）. There was no obvious adverse reaction. Conclusions： On the basis of conventional therapy, addition of BCG-PSN combined with compound Glycyrrhizin in treatment of chronic eczema has a good efficiency and high safety, and is well worthy clinical popularizing.