长期应用小剂量辛伐他汀治疗高脂血症的观察

Observation of low dosage of simvastatin on long term management in treatment of hyperlipidemia

目的：观察长期应用国产小剂量辛伐他汀结合调整给药方法对高脂血症患者治疗的有效性及安全性。方法：选择我院所服务的社区自愿接受他汀治疗的高脂血症患者,给予国产辛伐他汀10 mg·d-1,每晚1次顿服,每月服20 d,停10 d,循环往复,其中36例服药3~24个月;分析治疗前后血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL-C）、天门冬氨酸氨基转移酶（ALT）、肌酸激酶（CK）变化。结果：治疗后TC、TG、LDL-C等水平较治疗前下降,差异有统计学意义（P〈0.05）,ALT、CK水平治疗前后无改变（P〉0.05）。结论：调整国产小剂量辛伐他汀治疗方法后,高脂血症患者在一定程度达标的状态下,可达到长期调脂的目的,兼顾了效益—费用—风险,且患者服药依从性良好。

Objective： To observe the safety and efficacy of low dosage of simvastatin on long term management in treatment of hyperlipidemia. Method： Thirty-six patients were diagnosed with hyperlipidemia and consented to participate in this study. Simvastatin was given in 10 mg · d^-1 every night for consecutive 20 days, and then stopped for 10 days before retaking simvastatin again for 3 to 24 months. Total cholesterols （TC）, triglyceride （TG）, low density lipoprotein （LDL-C）, alanine aminotransferase （ALT） and serum creatine kinase （CK） were analyzed before and after the treatment. Results： TC, TG and LDL- C were significantly reduced （ P 〈 0. 05 ）, while ALT and CK were not significantly elevated （P 〉 0. 05 ）. Conclusion： Low dosage of generic simvastatin is safe and effective on long term management in treatment of hyperlipidemia. The regimentation is safe, cost-effective and easy to comply .