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巨噬细胞移动抑制因子及幽门螺杆菌致溃疡性结肠炎的相关性研究 被引量:1

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摘要 目的 探讨巨噬细胞移动抑制因子(MIF)和幽门螺杆菌(Hp)感染在溃疡性结肠炎(UC)发病中的临床意义.方法 共有160例研究对象纳入本研究,包括UC组患者和对照组患者各80例.采用酶联免疫吸附测定方法检测MIF,采用13C呼气试验检测Hp.结果 UC组患者血清MIF水平高于对照组患者[(10.6±1.9) μg/L比(5.4±1.8)μg/L],差异有统计学意义(t=17.77,P<0.01).UC组患者Hp阳性率低于对照组患者[28.75%(23/80)比56.25% (45/80)],差异有统计学意义(x2=12.38,P< 0.01).Hp阳性患者血清MIF水平低于Hp阴性患者[(6.4±1.5)μg/L比(9.6±1.7)μg/L],差异有统计学意义(t=10.77,P<0.01).结论 MIF参与了UC的发病,可能是UC活动的指标,可作为临床判断疾病严重程度及疗效的指标.Hp感染可能对UC的发生起预防作用.
作者 王明泽
出处 《中国医师进修杂志》 2014年第35期65-66,共2页 Chinese Journal of Postgraduates of Medicine
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