病毒感染与呼吸机相关肺炎的相关性研究

Study on the relationship between virus infection and ventilator-associated pneumonia （VAP）

目的 探讨病毒感染在VAP中的发生情况,总结病毒感染与VAP的相关性.方法 将35例应用呼吸机治疗未发生肺炎患者作为对照组及35例发生肺炎患者作为观察组,对比两组呼吸道合胞病毒（RSV）、腺病毒（ADV）、单纯疱疹病毒Ⅰ型（HSV-I）、巨细胞病毒（CMV）Ig-M的阳性率,并分析RSV、ADV、HSV-I、CMV与VAP发生的相关性.结果 VAP组RSV、ADV、HSV-I、CMV阳性率分别为5.57％、8.57％、22.85％及11.43％,总阳性率为48.57％,而对照组阳性率分别为2.85％、2.85％、5.57％及2.85％,总阳性率为14.19％,VAP组各病毒阳性率均明显高于对照组（P＜0.05）.同时HSV-I阳性与VAP均存在显著的正向直线相关性（P＜0.05）,而RSV、CMV及ADV阳性与VAP无相关关系（P＞0.05）.结论 VAP患者病毒感染阳性率明显升高,且HSV-I感染与VAP发生存在显著的相关性,提示HSV-I感染可能为VAP发生的危险因素.

Objective To investigate the correlation between virus infection and VAP summary.Methods 35 patients using respirator treatment without pneumonia were collected as control group,and 35 patients using respirator treatment with pneumonia were collected as research group.Ig-M of respiratory syncytial virus （RSV）,adenovirus （ADV）,herpes simplex virus type Ⅰ （HSV-I）,cytomegalovirus （CMV） were detected and the data was analyzed.Results Ig-M of RSV,ADV,HSV-I and CMV were 5.57%,8.57%,22.85% and 11.43% for the research group,2.85%,2.85%,5.57% and 2.85% for the control group.At the same time,there was linear correlation between HSV-I positive and VAP positive （P 〈 0.05）.Conclusions There was significant correlation between VAP patients with virus infection.