炎症标志物检测对2型糖尿病早期肾脏疾病诊断的临床意义

Clinical significance of inflammatory markers for early diagnosis of kidney disease in patients with type 2 diabetes

目的探讨炎症标志物检测对于2型糖尿病(T2DM)早期肾脏疾病诊断的临床意义。方法 2011年3月至2013年3月绵阳市中医医院收治的100例糖尿病患者,随机分成观察组和对照组,观察组50例为糖尿病肾脏疾病患者,对照组50例为非糖尿病肾脏疾病患者,选取同期50例健康体检人员作为健康组,对3组血清单核细胞趋化蛋白1(MCP-1)、肿瘤坏死因子α(TNF-α)、内毒素(LPS)等炎症标志物进行比较。结果观察组和对照组炎症标志物水平明显高于健康组,比较差异具有统计学意义(P<0.05);观察组炎症标志物水平明显高于对照组,比较差异具有统计学意义(P<0.05);UAlb/Cr与MCP-1、TNF-α、LPS、hs-CRP、AGI、PAI-1呈显著正相关(均P<0.05)。结论早期血清炎症标志物检测对于2型糖尿病早期肾脏疾病诊断和及时治疗具有重要意义。

Objective To explore the clinical significance of inflammatory markers for early diagnosis of kidney disease in patients with type 2 diabetes （T2DM ） .Methods A total of 100 patients ,treated in Mianyang Hospital of T .C .M .from Mar .2011 to Mar .2013 ,were enrolled in this study ,and divided into observation group（including 50 patients with diabetic kidney disease） and control group（including 50 patients without diabetic kidney disease） .Other 50 cases of healthy people in the corresponding period were selected into healthy group .The levels of serum monocyte chemoattractant protein 1 （MCP‐1） ,tumor necrosis factor α （TNF‐α） ,endotoxin （LPS） and other inflammatory markers were detected and compared among the three groups .Results The levels of inflammatory markers in the ob‐servation group and control group were obviously higher than those in the healthy group ,with significant difference （P〈0 .05）;and the levels of inflammatory markers in the observation group were also obviously higher than those in the control group ,with significant difference（P〈0 .05） .Significant positive correlations were observed between lev‐els of UAlb /Cr and levels of MCP‐1 ,TNF‐α,LPS ,hs‐CRP ,AGI and PAI‐1（P〈0 .05） .Conclusion Early detection of serum inflammatory markers for kidney disease in patients with type 2 diabetes could be benefit for the early diag‐nosis and treatment of diabetic kidney disease .