视黄醇结合蛋白检测在肾病综合征患儿诊断中的临床意义

Clinical significance of retinol-binding protein detection for diagnosis of nephrotic syndrome in children

目的：探讨视黄醇结合蛋白检测在肾病综合征患儿诊断中的临床意义。方法选择2013年1～12月在涿州市中医院确诊为肾病综合征的患儿60例为试验组（单纯型肾病综合征组33例，肾炎型肾病综合征组27例），另选择30名健康儿童设为健康对照组，分别测定其血清视黄醇结合蛋白、尿素和肌酐水平并进行比较分析。结果试验组两组患儿的血清视黄醇结合蛋白、尿素和肌酐浓度水平均高于健康对照组，且试验组两组患儿的血清视黄醇结合蛋白阳性检出率均高于尿素和肌酐阳性检出率，比较差异均有统计学意义（P＜0．05）；试验组患儿治疗后其血清视黄醇结合蛋白水平与治疗前比较明显降低，差异有统计学意义（P＜0．05），另外可见患儿血清视黄醇结合蛋白水平变化与临床表现存在一定的相关性（r＝0．7993，P＜0．05）；ROC曲线分析可见，3种血清学指标对肾病综合征的诊断效率由高到低依次为肌酐、视黄醇结合蛋白、尿素。结论血清视黄醇结合蛋白对肾病综合征的临床诊断和疗效监测都具有积极的临床价值。

Objective To explore the clinical significance of retinol‐binding protein detection for diagnosis of nephrotic syndrome in children .Methods A total of 60 cases of children with nephrotic syndrome were enrolled in the experimental group and divided into two groups （33 cases for the simple type nephrotic syndrome group and 27 cases for the nephritic type nephrotic syndrome group） .And other 30 cases of healthy children were selected as the healthy control group .The levels of retinol‐binding protein ,urea and creatinine were detected and analyzed .Results The levels of serum retinol‐binding protein ,urea and creatinine were higher in two experimental groups than those in healthy control group ,and in the two experimental groups the positive detectable rate of serum retinol‐binding protein was higher than that of urea and creatinine ,all with significant difference（P〈 0 .05） .The levels of serum retinol‐binding protein detected after treatment were evidently higher than those detected before treatment（P〈0 .05） ,and a certain correlation was found between levels of serum retinol‐binding protein and the clinical feature （r=0 .799 3 ,P〈0 .05） .The diagnostic efficiency of retinol‐binding protein was the highest ,followed by urea and creatinine .Conclu‐sion The retinol binding protein detection could be with positive clinical value for the clinical diagnosis and thera‐peutic morniteration of children with nephrotic syndrome .