摘要
目的:通过检测卵巢癌患者常规凝血指标及血浆中 D-二聚体水平,探讨血浆 D-二聚体及凝血指标在卵巢癌患者中的临床应用价值。方法测定84例卵巢癌患者和25例卵巢良性肿瘤患者,分析凝血功能水平、血浆 D-二聚体水平,评估手术前血浆 D-二聚体水平在监测卵巢癌病程中的应用价值。结果卵巢癌组 D-二聚体及纤维蛋白原(FBG)水平明显高于良性肿瘤对照组(P <0.01);并且卵巢癌Ⅲ~Ⅳ期患者 D-二聚体及 FBG 水平均高于卵巢癌Ⅰ~Ⅱ期患者,差异有统计学意义(P <0.05),提示卵巢癌患者凝血及纤溶功能障碍随病情发展呈现加重趋势。结论 D-二聚体在卵巢肿瘤时可以反映纤溶功能的过度激活,提示晚期卵巢癌患者的生存期和预后效果。D-二聚体水平在卵巢癌发生血栓的早期预防、早期诊断、早期治疗及提高预后有重要意义。
Objective To investigate the application value of plasma D-dimer and coagulation indicators in the patients with o-varian cancer by detecting the routine coagulation indicators and plasma D-dimer level.Methods The plasma D-dimer and coagula-tion indicators levels were measured in 84 patients with ovarian cancer and 25 patients with benign ovarian tumor.The application value of preoperative plasma D-dimer level in monitoring the disease course of ovarian cancer was evaluated.Results The plasma levels of D-dimer and FBG in the ovarian cancer group were significantly higher than those in the ovarian benign tumor control group(P 〈0.01);moreover the plasma levels of D-dimer and FBG in the patients with the stage Ⅲ~Ⅳ ovarian cancer were signifi-cantly higher than those in the patients with the stageⅠ~Ⅱ ovarian cancer,the differences had statistical significance(P 〈0.05), which prompting that the coagulation and fibrinolysis dysfunction in the patients with ovarian cancer exhibited the aggravating trend with the disease condition progression.Conclusion D-dimer may reflect the excessive activation of fibrinolysis function in ovarian tumor,which prompting the survival period and prognosis in the patients with advanced ovarian cancer.The plasma D-dimer level has the important significance to early prevention,early diagnosis,early treatment and improve the prognosis in the thrombosis oc-currence in ovarian cancer.
出处
《国际检验医学杂志》
CAS
2014年第24期3307-3308,共2页
International Journal of Laboratory Medicine
基金
国家自然科学青年基金资助项目(81202039)
黑龙江省自然科学基金资助项目(QC2012C037)
关键词
卵巢癌
凝血功能
D-二聚体
ovarian cancer
coagulation function
D-dimer