期刊文献+

血栓前体蛋白与糖尿病微血管病变关系的研究 被引量:1

Research on relationship between thrombus precursor protein with diabetic microangiopathy
下载PDF
导出
摘要 目的:检测糖尿病微血管病变患者体内血栓前体蛋白(TpP)浓度,探讨 TpP 浓度变化与糖尿病微血管病变之间的关系以及与糖尿病伴发脑梗死之间的关系。方法研究对象为2013年7~12月该院内分泌科和神经内科住院的136例糖尿病微血管病变患者,并选取体检中心58例健康体检者作为对照组。分别检测血清中的 TpP、纤维蛋白原(Fib)、D-二聚体浓度和血浆凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)。采用 SPSS14.0软件包进行统计学处理,分析各项指标浓度变化在各组间差异有无统计学意义。结果(1)TpP 浓度在糖尿病微血管病变组明显升高,与对照组比较,差异有统计学意义(P <0.05)。而两组之间 Fib、D-二聚体、PT、APTT 比较差异均无统计学意义(P >0.05)。(2)根据是否合并脑梗死将糖尿病微血管病变组分为2个亚组,TpP 浓度在糖尿病微血管病变合并脑梗死组明显高于未合并脑梗组,差异有统计学意义(P <0.05)。结论 TpP 浓度在糖尿病微血管病变组明显高于对照组,说明机体处于高凝状态,有血栓形成的潜在危险。糖尿病患者检测血浆 TpP 浓度的改变有助于血栓性疾病的早期发现和及时治疗。 Objective To detect the serum thrombus precursor protein(TpP)level in the patients with diabetic microangiopathy and to investigate the relationship between the changes of TpP concentrations and the diabetic microangiopathy.Methods 136 ca-ses of diabetic microangiopathy in the endocrinology and neurology departments of our hospital from July to December 2013 were selected as the research subjects and 58 healthy individuals with physical examination were selected as the normal control group(NC group).The serum TpP,Fib,D-dimer concentrations and PT,APTT were measured.The SPSS14.0 software package was adopted to perform the statistical processing.Results (1).Serum TpP concentration in the diabetic microangiopathy group was significantly higher than that in the NC group with statistical difference(P 〈0.05).There was no statistical differences in Fib,D-dimer,PT and APTT between the two groups(P 〉0.05).(2).According to whether or not complicating cerebral infarction,the diabetic microan-giopathy group was divided into two subgroups.and diabetic not merged cerebral infarction group.Serum TpP concentrations in the complicating cerebral infarction subgroup was significantly higher than that in the non-complicating cerebral infarction subgroup with statistical difference(P 〈0.05 ).Conclusion The serum TpP concentration in the diabetic microangiopathy is significantly higher than that in the control group,which indicating that the patient is in a hypercoagulable status the risk of thrombosis.The TpP detection may contribute to early diagnosis and timely treatment of thrombotic diseases for these patients.
作者 张秀岭
出处 《国际检验医学杂志》 CAS 2014年第24期3343-3344,共2页 International Journal of Laboratory Medicine
关键词 血栓前体蛋白 糖尿病 糖尿病微血管病变 脑梗死 血栓 thrombus precursor protein diabetes mellitus diabetic microangiopathy cerebral infarction thrombus
  • 引文网络
  • 相关文献

参考文献9

二级参考文献46

共引文献79

同被引文献6

引证文献1

;
使用帮助 返回顶部