不同性别冠心病患者脂蛋白(a)与纤维蛋白原的表达及其临床意义

Expression of lipoprotein(a)and fibrinogen in different genders of patients with coronary heart disease and its clinical significance

目的探讨不同性别冠心病患者脂蛋白(a)与纤维蛋白原的表达及其临床意义。方法选取该院2009年1月至2013年12月诊治的冠心病患者1 500例为观察组,其中男954例,女546例。选取该院同期健康体检人员500例为对照组,其中男329例,女171例。均行心肌酶谱、血脂、凝血功能及多种蛋白检测。结果无论是男性还是女性,观察组患者CK、CKMB、AST、LDH、α-HBDH、TC、TG、LDL-C、FIb、D-D、TT、FDP、LPa、cTnI、MYO、HCY均明显高于对照组,观察组患者HDL-C、APTT、INR、PT均明显低于对照组,差异均有统计学意义(P<0.05)。结论无论是男性还是女性,冠心病患者均存在不同程度的心肌酶谱指标、血脂指标、凝血功能指标、载脂蛋白、肌钙蛋白、肌红蛋白和同型半胱氨酸异常表达。脂蛋白(a)与纤维蛋白原在冠心病患者中存在高表达,可为患者疾病的诊治提供可靠的科学依据。

Objective To investigate the expression of lipoprotein（a）and fibrinogen different genders of patients with coronary heart disease（CHD）and its clinical significance.Methods 1 500 patients with CHD in the hospital from January 2009 to December 2013 were selected as the observation group,including 954 males and 546 females.Contemporaneous 500 healthy people with physi-cal examination were selected as the control group,including 329 males and 171 females.The myocardial enzymes,serum lipid,blood coagulation function and various proteins were detected.Results Whether males or females,CK,CKMB,AST,LDH,α-HBDH, TC,TG,LDL-C,Fib,D-D,TT,FDP,LPa,cTnI,MYO and HCY in the observation group were significantly higher than those in the control group.HDL-C,APTT,INR and PT in the observation group were significantly lower than those in the control group.The differences were statistically significant（P 〈0.05 ）.Conclusion Whether males or females,the different degrees of abnormal ex-pression of myocardial enzyme spectral indexes,blood lipid indexes,coagulation indexes,apolipoprotein,troponin,myoglobin and ho-mocysteine exist in the patients with CHD.Lipoprotein（a）and fibrinogen have high expression in the CHD patients,which can pro-vide the reliable scientific basis for diagnosis and treatment of the disease.