3595例孕中期妇女产前筛查结果分析

Analysis of prenatal screening results in 3595 middle pregnant women

目的通过检测孕中期孕母血清甲胎蛋白(AFP)、β-人绒毛膜促性腺激素(β-HCG)、非偶联雌三醇(uE3)水平,探讨产前筛查临床应用价值。方法采用化学发光法对3 595例孕中期孕妇进行血清AFP、β-HCG、uE3定量检测,结合孕妇年龄、孕周、体质量等因素,计算风险值。随后对高风险孕妇进行羊水细胞染色体核型分析及B超检查。结果 3 595例孕妇唐氏综合征(DS)、爱德华综合征(ES)、先天性神经管缺陷(NTD)筛查阳性率分别为3.70%(133/3 595)、0.11%(4/3 595)和1.44%(52/3 595)。产前筛查189例为高风险孕妇,其中87例进行染色体核型分析、超声影像等产前诊断,确诊6例,其中DS 3例、NTD 2例、ES 1例。结论产前筛查是一种无创伤性检测手段,对避免DS、ES、NTD患儿出生有重要临床应用价值。

Objective To explore the clinical value of prenatal screening by detecting α-fetoprotein（AFP）,β-human chorionic gonadotrophin（β-HCG）and free estriol（u-E3）levels in the second trimester of pregnancy.Methods AFP,β-HCG and u-E3 were de-tected in 3 595 second trimester pregnant women by chemiluminescence.The risk value was calculated by combining with the factors of age,pregnant weeks,body weight,etc.Then the high-risk pregnant women were carried out the amniotic fluid cells chromosome karyotype analysis and B-ultrasonic examination.Results Among 3 595 pregnant women,the screening positive rates of Down′s syndrome（DS）,Edward′s syndrome（ES）and neural tube defects（NTD）were 3.70%（133/3 595）,0.11%（4/3 595）and 1.44%（52/3 595）respectively.In the prenatal screening,there were 189 cases of high risk pregnant women,among them 87 cases were per-formed the prenatal diagnosis of amniotic fluid cells chromosome karyotype analysis and B-ultrasonic examination,6 cases were defi-nitely diagnosed,in which 3 cases were DS,2 cases were NTD and 1 case was ES.Conclusion Prenatal screening is a non-invasive detection method and has the important clinical application value for avoiding the birth of DS,ES and NTD neonates.