期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Cys-C、尿Ⅳ-C、尿NAG在糖尿病肾病早期诊断中的应用 被引量：3

下载PDF
导出
摘要 目的探讨血胱抑素C(Cys-C)、尿Ⅳ型胶原(Ⅳ-C)、尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)检测在糖尿病肾病早期诊断中的应用。方法利用生化分析仪和酶联免疫分析仪,分别测定49例早期糖尿病患者和28例健康人的Cys-C、尿Ⅳ-C、尿NAG和mALB数值,用SPSS19.0进行统计分析。结果 Cys-c、尿Ⅳ-C和尿NAG的数值,Ⅱ组与Ⅰ组相比,Ⅱ组与健康组相比均有显著性增高(P<0.01),Ⅰ组与正常组比较增高均有统计学意义(P<0.05),Ⅱ组Cys-C、尿Ⅳ-C和尿NAG与mALB相关性分别为0.830、0.849、0.834。结论 Cys-c、尿Ⅳ-C、尿NAG可以分别测定肾脏不同部位的损伤,在早期诊断糖尿病肾病方面灵敏度高,且与mALB有同等诊断价值,有助于发现早期糖尿病肾病损害。
作者 王勇 李东阳
机构地区 天津市泰达医院检验科
出处 《国际检验医学杂志》 CAS 2014年第24期3441-3443,共3页 International Journal of Laboratory Medicine
关键词 糖尿病肾病 血胱抑素C 尿IV型胶原 尿N-乙酰-Β-D氨基葡萄糖苷酶
分类号 R587.2 [医药卫生—内分泌]
  • 相关文献

参考文献8

二级参考文献33

  • 1章毅,王永志.根据血清胱抑素C浓度推测肾小球滤过率的临床应用[J].中国血液净化,2004,3(12):655-656. 被引量：52
  • 2李海霞,张春丽,徐国宾,王学晶,李淑葵,李志艳,张旭初,夏铁安.健康人群血清半胱氨酸蛋白酶抑制剂C与肌酐分布及其评价慢性肾脏病患者肾小球滤过功能的比较研究[J].中华检验医学杂志,2006,29(11):970-974. 被引量：179
  • 3Futrakul N, Futrakul P. Diagnostic markers for early detectlon of diabetic retinopathy and nephropathy. Clin Nephrol,2008,69( 1 ): 63-64.
  • 4Mohammadi-Karakani A, Asgharzadeh-Haghighi S, Ghazi-Khansari M, et al. Determination of urinary enzymes as a marker of early renal damage in diabetic patients. J Clin Lab Anal, 2007,21 (6):413- 417.
  • 5Dharnidharka VR, Kwon C, Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta- analysis. Am J Kidney Dis, 2002,40(2 ) : 221-226.
  • 6Thomas MC, Burns WC, Cooper ME. Tubular changes in early diabetic nephropathy. Adv Chronic Kidney Dis, 2005,12 (2) : 177- 186.
  • 7Tassi C, Abbritti G, Mancuso F, et al. Activity and isoenzyme profile of N-acetyl- beta-D-glucosaminidase in urine from workers exposed to cadmium. Clin Chim Acta, 2000,299(1/2) : 55-64.
  • 8Rigalleau V, Beauvieux MC, Le Moigne F, et al. Cystatin C improves the diagnosis and stratification of chronic kidney disease, and the estimation of glomerular filtration rate in diabetes. Diabetes Metab, 2008,34 (5) : 482-489.
  • 9Hayashi H, Karasawa R, Inn H, et al. An electron microscopic study of glomeruli in Japanese patients with non-insulin dependent diabetes mellitus[J]. Kidney Int, 1992, 41(4) :749 -757.
  • 10Mauer SM, Steffes MW, Ellis EN, et al. Structural-functional relationships in diabetic nephropathy[ J ]. J Clin Invest, 1984, 74 (4) :1143 - 1155.

共引文献263

同被引文献51

  • 1付松柏,周玉珠,刘伣,任野萍.尿mALB、α_1-MG、TRF、NAG检测对糖尿病肾病早期诊断的价值[J].黑龙江医学,2006,30(4):255-257. 被引量：7
  • 2Titan SM, Vieira JM, Dominguez WV, et al. Unnary MCP - 1 and RBP: independent predictors of renal outcome in maeroalbuminmie diabetie nephropathy [ J]. J Diabetes Complications, 2012, 26 (6) : 546 - 553.
  • 3Branten AJ, Vervoort G, Wetzels JF. Serum ereatinine is a poor marker of GFR in nephrotic syndrome[ J ]. Nephrol Dial Trans- plant, 2005, 20 (4) : 707 - 711.
  • 4Laterza OF, Price CP, Scott MG. Cystatin C: an improved estima- tor of glomerular filtration ra, te? [ J]. Clin Chem, 2002, 48 (5) : 699 - 707.
  • 5Lisowska - Myjak B. Serum and urinary, biomarkers of acute kidney injury[ J]. Blood Purlf, 2010, 29(4): 357 -365.
  • 6Tramonti G, Kanwar YS. Review and discussion of tubular biornar- kers in the diagnosis and management of diabetic nephropathy [ J ]. Endocrine, 2013, 43(3): 494-503.
  • 7Akerstr;Sm B, Logdberg LE, Bergghrd I, et aL alpha( 1 ) - Micro- globulin: a yellow- brown lipocalin [ J ]. Biochim Biophys Acta, 2000. 1482( 1/23, 172 - 184.
  • 8Endre ZH,Westhuyzen J. Early detection of acute kidneyinjury: emerging neW biomarkers [J]. Nephrology ( Carl-ton) ,2008,13(2) :91-98.
  • 9Bellomo R,Ronco C,Kellum JA?et al. Acute renal failure-definition,outcome measures,animal models,fluid therapyand information technology needs:the Second Internation-al Consensus Conference of the Acute Dialysis Quality In-itiative( ADQI) Group [J]. Crit Care, 2004, 8 (4): R204-212.
  • 10Palevsky PM, Liu KD, Brophy PDK,et al. KDOQI UScommentary on the 2012 KDIGO clinical practice guide-line for acute kidney injury[J]. Am J Kidney Dis,2013 ,61(5):649-672.

引证文献3

二级引证文献23

国际检验医学杂志
2014年 第24期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部