摘要
目的观察快速康复外科(FTS)对老年结直肠癌根治手术患者机体免疫功能的影响。方法将40例老年结直肠癌患者随机分成两组,即对照组(20例)和FTS组(20例)。两组分别于术前、术后第3d和第7d取外周静脉血,测定C反应蛋白(CRP)、免疫球蛋白(Ig G、Ig A、Ig M)以及CD4+等。结果两组患者术后第3和第7d CRP较术前均升高(P<0.05),与FTS组对比,对照组升高更加明显(P<0.05)。两组患者免疫球蛋白于术后第3d较术前均明显降低(P<0.05),与FTS组比,对照组降低更明显(P<0.05),术后第7d,FTS组免疫球蛋白恢复至术前水平,而对照组仍明显低于术前(P<0.05)。两组患者术后第3d CD4+较术前明显降低(P<0.05),与FTS组比,对照组降低更明显(P<0.05),术后第7d,FTS组CD4+恢复至术前水平,而对照组仍明显低于术前(P<0.05)。结论老年结直肠癌患者应用FTS理念可保护免疫功能,加速患者术后康复。
Objective To investigate the influence of fast tract surgery on the immune function in aged patients with colorectal cancer. Methods 40 patients were randomized to control group（n=20） and FTS group（n=20）.CRP,IgG,IgA,IgM,CD4＋were tested before operation and postoperative day 3 and postoperative day 7. Results On the day 3,7 postoperatively,CRP significantly increased as compared to those preoperatively in two groups （P＜0.05）,but the parameters in control group were significantly higher than those in FTS group （P＜0.05）. On the day 3 postoperatively,IgG,IgA,IgM significantly decreased as compared with those preoperatively in two groups（P＜0.05）,and the parameters in control group were significantly lower than those in FTS group（P＜0.05）. On the day 7,there was no significant difference of IgG,IgA,IgM between before and after operation in FTS group（P ＞0.05） ,but the parameters in control group were significantly lower than those preoperatively. On day 3 postoperatively,CD 4 ＋ significantly decreased as compared to those preoperatively in two groups （P＜0.05）,and the parameters in control group were significantly lower than those in FTS group（P＜0.05）. The levels of CD4＋recovered rapidly in FTS group on the day 7 postoperatively（P ＞0.05）,but the parameters in control group were significantly lower than those preoperatively （P＜0.05）. Conclusion Fast track surgery for aged patients with colorectal cancer can preserve immunity,and accelerates postoperative rehabilitation.
出处
《江西医药》
CAS
2014年第11期1125-1127,共3页
Jiangxi Medical Journal
基金
江西省科学技术厅科技支撑项目(2009ZDS15600)
