一清胶囊联合复方维A酸凝胶治疗并发便秘的痤疮75例

Clinical Efficacy Observation of Yiqing Capsule and Compound Tretinoin Gel in the Treatment of Acne with Concomitant Constipation

目的观察一清胶囊治疗并发便秘的痤疮患者的临床疗效与安全性。方法采用随机对照的方法将145例并发便秘的痤疮患者分为治疗组和对照组,治疗组(75例)予一清胶囊口服联合外用复方维A酸凝胶,对照组(70例)单外用复方维A酸凝胶作对照,均治疗3周。结果治疗组痤疮的疗效明显优于对照组(P<0.01),两组均未出现明显不良反应。治疗组77.4%患者便秘症状明显改善,高于对照组(P<0.01),治疗组和对照组中便秘改善者痤疮的治疗效果均明显优于便秘未改善者(P<0.01),痤疮疗效与便秘改善情况的Spearman相关系数为0.699(P<0.01)。结论一清胶囊联合复方维A酸凝胶治疗痤疮疗效肯定,无明显不良反应,改善便秘进而明显提高对痤疮的疗效。

Objective To observe the clinical efficacy and safety of yiqing capsule in the treatment of acne with concomitant constipation. Methods A randomized controlled method was used. One hundred and forty-five patients with acne and concomitant constipation were randomized into treatment group（ n = 75） and control group（ n = 70）. Patients in the treatment group received yiqing capsule orally and compound tretinoin gel topically,while patients in the control group received topical compound tretinoin gel only. Both groups were treated for 3 weeks. Results The therapeutic effect of the treatment group was much better than that of control group（ P〈0. 01）. No obvious adverse reactions were observed in either group. In the treatment group,77. 4% of patients were relieved from constipation,the ratio being much higher than the control group（ P〈0. 01）. The chance of acne relief was remarkably higher in patients whose constipation were relieved（ P〈0. 01）. The Spearman correlation index between acne relief and constipation improvement was 0. 699（ P〈0. 01）. Conclusion Combination therapy of yiqing capsule and compound tretinoin gel is effective in the treatment of acne with no significant adverse reactions. The constipation improvement from yiqing capsule can contribute to the efficacy towards acne.