摘要
表面增强拉曼散射(surface-enhanced Raman scattering,SERS),是指吸附在粗糙的金属纳米结构表面的被分析物,在光照射下其拉曼光谱获得显著增强的异常表面光学现象。近年来,SERS技术已广泛地用于物质检测和生物传感等研究,在生物医学领域表现出巨大的应用潜力并取得了令人瞩目的研究成果。本文回顾了SERS探针技术在细胞识别、成像与诊疗等方面的应用及最新研究进展,重点介绍了SERS细胞探针的构建方法与原理,以及基于SERS探针的细胞检测应用策略,并讨论了SERS探针技术在细胞检测中仍有待解决的关键问题。
Surface-enhanced Raman scattering（ SERS） refers to an abnormal surface optical phenomenon that Raman spectra of the analyte adsorbed on metal nanostructures can be significantly enhanced under laser irradiation. In recent years,SERS has been widely used in the substance detection and biological sensing,which has achieved significant development and shown great potential applications in the biomedical field. In this paper,the preparation principle and the latest development of SERS tags used in cell detection are introduced,and their recent applications in cell recognition,imaging,diagnosis and treatment are reviewed,as well as the detection strategies and issues related to SERS tag-based cell detection are discussed.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2015年第1期91-102,共12页
Progress in Chemistry
基金
国家重点基础研究发展计划(973)项目(No.2012CB933301)
国家自然科学基金项目(No.61302027
21305070
21475064)
江苏省自然科学基金项目(No.BK20130871)
"有机与生物光电子学"教育部创新团队项目(IRT1148)
生物电子学国家重点实验室开放研究基金(2013G2)
江苏省科技支撑计划(No.BE2014719)
江苏高校优势学科建设工程(PAPD)
南京邮电大学科研启动基金(NY212032)资助~~
关键词
表面增强拉曼散射
SERS探针
细胞识别
成像
诊疗
surface-enhanced Raman scattering
SERS tag
cell recognition
imaging
diagnosis and treatment
