XRCC1基因SNP399多态性与高加索人脑胶质瘤易感性关系

XRCC1 Gene SNP399 Polymorphism and the Risk of Glioma：A Meta-Analysis

目的：探讨XRCC1基因SNP399多态性和高加索人胶质瘤易感性的关系。方法提取XRCC1基因SNP399多态性与脑胶质瘤易感性关系的数据，筛选出符合条件的数据，应用Meta分析技术软件对各项数据进行异质性检验，计算合并相对危险度（OR）值及95%可信区间（CI），并行敏感性分析和发表偏移的评估。结果该研究中共有6组符合条件的数据，病例组2,362例、对照组3,085例。Meta分析合并结果显示，XRCC1基因SNP399多态性在等位基因模型（P=0.03，OR=1.14，95%CI 1.03～1.28，P异质性=0.006）和隐性基因模型（P=0.006，OR=1.17，95%CI 1.05～1.30，P异质性＜0.00007）下能够增加高加索人种脑胶质瘤的发病风险。敏感性分析表明合并结果不受单个研究的影响。结论 XRCC1基因SNP399多态性能够增加高加索人脑胶质瘤的发病风险。

Objective To explore the association between XRCC1 gene SNP399 polymorphism and the risk of glioma. Methods Studies on the association between XRCC1 gene SNP399 polymorphism and the risk of glioma were searched and all relevant studies that met the inclusion criteria were eligible for the analysis. Four genetic models and generalized odds ratios （ORs） and 95%confidence interval （CIs） were used for the assessment. At last, we conduct sensitivity analysis and investigate the publication bias. Results A total of 6 articles with a total of 2,362 cases and 3,085 controls were included. XRCC1 gene SNP399 polymorphism contributed to glioma susceptibility in Caucasian population when allele model （G versus A）, recessive model （GG versus GA and AA） were applied （G versus A：P=0.03, OR=1.14, 95%CI 1.03~1.28, Pheterogeneity=0.006;GG versus GA and AA：P=0.006, OR=1.17, 95%CI 1.05~1.30, Pheterogeneity〈0.00007）, sensitivity analysis show this result was not influenced by one study. Conclusion The present meta-analysis suggests that XRCC1 gene SNP399 polymorphism is associated with increased glioma risk in Caucasian population.