子痫前期患者血脂、超敏-C反应蛋白和心肌肌钙蛋白I水平的临床研究

Clinical Study of Blood Lipid, hs-CRP and cTnI Levels in Patients with Pre-eclampsia

目的：探讨子痫前期患者治疗前后血脂和血浆超敏-C反应蛋白（hs-CRP）、心肌肌钙蛋白I（cTnI）水平的临床意义。方法2012年1月～2013年6月轻度子痫前期组患者35例、重度子痫前期组37例，酶循环法测定血清甘油三酯（TG）、胆固醇（TC），直接法测定低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C），免疫比浊法测定hs-CRP，化学发光法测定cTnI，60例正常孕妇为对照组。结果与对照组比较，治疗前，子痫前期患者TC、TG、LDL-C、hs-CRP、cTnI增高，HDL-C降低（P＜0.01）；治疗后，轻度子痫前期组恢复正常（P＞0.05），重度子痫前期组除TG外，其他仍增高（P＜0.01）。重度子痫前期组与轻度子痫前期组比较，TC、TG、LDL-C、hs-CRP、cTnI较高， HDL-C低，差异均有统计学意义（P＜0.01）。结论子痫前期患者血脂、hs-CRP和cTnI水平是观察病情和疗效的量化指标。

Objective To explore the clinical significance of blood lipid, plasma hs-CRP and cTnI levels in patients with pre-eclampsia. Methods The blood lipid, hs-CRP and cTnI levels were determined in patients with pre-eclampsia （including 35 cases mild pre-eclampsia and 37 cases severe pre-eclampsia） and 60 controls by biochemistry, particle immune turbidity and chemiluminescence immunoassay as well as did compared analysis. Results Before therapy, the serum TC, TG and LDL-C levels in patients with pre-eclampsia were significantly higher than those in normal controls, but the serum HDL-C level was decreased （P〈0.01）. After ther apy, patients with mild pre-eclampsia return to normal levels （P〉0.05）. Those indexes in patients with severe pre-eclampsia still increase except TG （P〈0.01）. Compared with the patients with mild pre-eclampsia, the TC, TG, LDL-C, plasma hs-CRP and cTnI levels in patients with severe pre-eclampsia were higher, but the serum HDL-C level was lower. The difference between them had statistical significance （P〈0.01）. Conclusion Monitoring the blood lipid, hs-CRP and cTnI levels in patients with pre-eclampsia can get quantified indexes to observe the patient＂s condition and curative effect.