过敏性紫癜患儿急性期细胞免疫功能变化及临床意义

Clinical Significance of Cellular Immune Function in Acute Phase of Henoch-Schonlein Purpura in Children

目的：探讨过敏性紫癜（HSP）患儿急性期外周血淋巴细胞免疫功能变化及其临床意义。方法采用流式细胞术法分别测定32例HSP患儿急性期外周血T细胞亚群CD3＋T细胞、CD4＋T细胞、CD8＋T细胞、CD4＋/CD8＋的水平，并与20名健康儿童比较分析。结果HSP患儿急性期外周血T细胞亚群CD4＋T细胞和CD4＋/CD8＋均降低，而CD8＋T细胞水平增高，与对照组比较差异有统计学意义（P＜0.05）；CD3＋T细胞差异无统计学意义（P＞0.05）。结论 HSP急性期存在细胞免疫功能紊乱，并且其可能为HSP的发病机制。

Objective To investigate the changes and clinical significance of peripheral lymphocyte immune function in Henoch-Schonlein purpura （HSP） children of acute phase. Methods The levels of peripheral CD3＋T cells, CD4＋T cells, CD8＋T cells, CD4＋/CD8＋in HSP children of acute phase （n=32） and healthy controls （n=20） were detected by flow cytometry. Results The levels of CD4＋T cells and CD4＋/CD8＋in HSP children of acute phase were significantly lower than those of controls （P〈0.05）, while the level of CD8＋T cells was significantly higher than those of controls （P〈0.05）. There is no significant difference in CD3＋T cells between HSP group and control group （P〉0.05）. Conclusion The HSP children of acute phase display the T-cell dysfunction, and it may involve in the pathogenesis of HSP.