老年人同型半胱氨酸相关危险因素分析

Analysis on risk factors of homocysteine in elderly people

目的调查分析东风公司退休职工健康检查人群中血浆总同型半胱氨酸(t Hcy)与高血压及其主要危险因素的关系。方法对9 328例退休职工进行空腹抽血查t Hcy,测定高血压、体重指数(BMI)、腰臀比值(WPH)及超体重。结果 t Hcy总阳性率为30.4%,其中男性t Hcy阳性率为45.6%,女性为18.8%,性别间t Hcy阳性率差异有统计学意义(P<0.01);t Hcy阳性率随年龄增长而上升,尤其以71岁后的男性最为突出,阳性率为51.8%。当t Hcy正常时,高血压的患病率为16.9%;当t Hcy异常时,高血压的患病为23.2%,两者之间差异有统计学意义(P<0.01)。从高t Hcy水平看,t Hcy对收缩压或舒张压有一定的影响,当t Hcy正常时,单纯收缩压升高为45.6%,单纯舒张压升高为18.1%;当t Hcy异常时,单纯收缩压升高为57.7%,单纯舒张压升高为24.7%,两者之间差异亦有统计学意义(P<0.01)。当BMI正常时,t Hcy阳性率为28.5%;当BMI异常时,t Hcy阳性率为33.3%,两者之间差异有统计学意义(P<0.01)。当WPH正常时,t Hcy阳性率为33.7%;当WPH异常时,t Hcy阳性率为28.2%,两者之间差异有统计学意义(P<0.01)。而超体重正常与异常时,t Hcy阳性率两者差异亦有统计学意义(P<0.05)。结论年龄、性别、WPH、BMI均是t Hcy的危险因素,与t Hcy的水平具有一定的关系。

[Objective]To investigate and analyze the relationship between plasma total homocysteine（t Hcy）and hypertension,as well as its major risk factors in retired workers of Dongfeng Automobile Company.[Methods]9328 retired workers were collected to detect t Hcy,blood pressure,body mass index（BMI）,Waist to hip ratio（WPH） and body weight.[Results]The total positive rate of t Hcy was 30.4%,the positive rate in males and females was 45.6% and 18.8% respectively,and the difference in males and females was significant（P0.01）. The positive rate increased with the increasing of age,and that in male workers over 71 years old reached 51.8%. The prevalence rate of hypertension was 16.9% when t Hcy was at normal level,while that was 23.2% when t Hcy level was abnormal,and the difference was significant（P〈0.01）. t Hcy had a certain influence on systolic pressure or diastolic pressure. The rate of simple systolic hypertension and simple diastolic hypertension was 24.7% and 45.6% respectively when t Hcy was at normal level,while that was 57.7% and 24.7% respectively when t Hcy level was abnormal,and the differences were significant（P〈0.01）. The positive rate of t Hcy was 28.5% among people with normal BMI value,while that was 33.3%among people with abnormal BMI value,and the difference was significant（P0.01）. The positive rate of t Hcy was 33.7% among people with normal WPH value,while that was 28.2% among people with abnormal WPH value,and the difference was significant（P0.01）. There was significant difference in positive rate of t Hcy between normal body weight group and abnormal body weight group（P0.05）.[Conclusion]Age,Sex,WPH and BMI are the risk factors of t Hcy,which are related to t Hcy level.