摘要
目的探讨Pim-3与XIAP在食管鳞癌组织中的表达及意义。方法采用免疫组织化学SABC法检测Pim-3与XIAP在食管鳞癌及正常食管黏膜中的表达。结果 Pim-3与XIAP在食管鳞癌中呈高表达,在正常食管黏膜中呈低表达,差异显著,具有统计学意义(P<0.01);Pim-3与XIAP的表达与食管鳞癌的组织学分级与临床病理分期无关。结论 Pim-3与XIAP参与食管鳞癌的发生发展,推测Pim-3与XIAP可以成为食管鳞癌诊断的新指标之一。
Objective To explore the expression and significance of Pim- 3 and XIAP in esophageal squamous cell carcinoma （ESCC）. Methods The expression of Pim- 3 and XIAP was detected in ESCC and normal esophageal mucosa tissues by SABC immunohistochemical technology. Results The Pim - 3 and XIAP presented high expression in ESCC, low expression in normal esophageal mucosa tissues, to compare the expression of them, there were remarkable differences and statistically significance（P 〈 0. 01） ; There was no correlations between the expression of Pim - 3 and XIAP in ESCC and the histological classification and clinical pathologic stage of the ESCC. Conclusion The Pim - 3 and XIAP involve in the occurrence and progression of ESCC, to speculate that the Pim- 3 and XIAP can become a new index of diagnosing ESCC.
出处
《内蒙古医学杂志》
2014年第12期1424-1427,共4页
Inner Mongolia Medical Journal
关键词
PIM-3
XIAP
食管鳞癌
免疫组织化学
Pim - 3
XIAP
esophageal squamous cell carcinoma
immunohistochemistry
