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微小RNA对骨重塑和炎症性骨吸收调控的研究进展 被引量：2

Progress research on regulation of microRNA on bone remodeling and inflammatory bone resorption
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摘要 微小RNA(miRNA)是一种通过沉默转录后基因表达发挥功能的重要调控因子,可调控成骨细胞介导的骨形成及破骨细胞相关的骨重塑过程。随着miRNA作用机制研究的不断深入,已经证明其为炎性骨病和代谢性骨病的重要发病因素。因此以miRNA为靶点治疗此类疾病将具有重要意义。本文阐述了miRNA的生成过程和作用机制,并对骨重塑的直接调控作用及炎症条件下miRNA间接调控骨重塑的功能和机制进行探讨。
作者 孙宏晨 方滕姣子 李道伟 朱阳 宫海环 张雪 马珊珊
机构地区 吉林大学口腔医院病理科
出处 《吉林大学学报（医学版）》 CAS CSCD 北大核心 2015年第1期195-198,I0004,共5页 Journal of Jilin University：Medicine Edition
基金 国家自然科学基金资助课题(81271111)
关键词 微小RNA 骨重塑 炎症性骨吸收 骨髓间充质干细胞 成骨细胞 破骨细胞
分类号 Q813 [生物学—生物工程]
  • 相关文献

参考文献33

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二级参考文献27

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共引文献2

同被引文献19

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二级引证文献1

吉林大学学报（医学版）
2015年 第1期

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