血清骨桥蛋白诊断卵巢癌的meta分析

Diagnostic Value of Osteopontin for Ovarian Cancer：a Meta-Analysis

目的评价血清骨桥蛋白（osteopontin，OPN）对卵巢癌的诊断价值。方法检索万方、维普和清华同方2014年5月以前发表的关于血清OPN诊断卵巢癌的文献。以QUADAS工具对文献进行质量评价，通过随机效应模型分析血清OPN诊断卵巢癌的总体敏感度、特异度、阳／阴性似然比和诊断优势比。以sROC曲线法分析血清0PN诊断卵巢癌的总体性能。结果该次meta分析共纳入6项研究，血清OPN诊断卵巢癌的总体诊断敏感度为0．83（95％可信区间：0．78～0．87），总体诊断特异度为0．91（95％可信区间：0．88～0．94），总体诊断阳性似然比为9．00（95％可信区间：5．91～13．71），总体诊断阴性似然比为0．19（95％可信区间：0．15～0．25），总体诊断优势比为47．58（95％可信区间：27．93～81．05）。SROC曲线下面积为0．87，Q值为0．80。结论血清OPN对卵巢癌具有较高的诊断价值。

Objective To evaluate the diagnostic performance of osteopontin （OPN） for ovarian cancer. Methods Wanfang, CQVIP and CNKI were retrieved to identify eligible studies on diagnostic value of OPN for ovarian cancer that published be- fore May,2014. The quality of the studies was evaluated by QUADAS tools. The diagnostic sensitivity, specificity, negative and positive likelihood ratios and diagnostic odds ratio （DOR） were pooled by random-effects models. The overall diagnostic performance was estimated by summary receiver operating characteristic （SROC） curves approaches. Results Six studies met the included criteria. The summary estimates for OPN in the diagnosis of ovarian cancer in the studies included were as follows ： sensitivity 0.83 [ （ 95 % confidence interval （CI） ： 0.78 ～ 0.87）], specificity 0.91 （ 95 % CI, 0.88 ～ 0.94）, positive likelihood ratio 9.00 （95% CI,5.91～13.71） ,negative likelihood ratio 0.19 （95% CI,0. 15～0.25） ,and DOR 47.58 （95% CI, 27.93～81.05）. The area under curve （AUC） for OPN was 0.87 with Q value of 0.80. Conclusion OPN has high diag- nostic value for ovarian cancer.