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兰州地区孕妇孕中期产前筛查结果回顾性分析 被引量:1

The results analysis at the second-trimester maternal prenatal screening retrospectively
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摘要 目的通过检测孕妇血清中AFP,Free-βh CG和u E3的浓度,对孕中期胎儿患DS、ES和NTD的风险进行评估。方法运用时间分辨荧光法定量测定孕妇血清中AFP,Free-βh CG和u E3的浓度,采用"Life cycle 3.2"软件计算风险。结果 9430例孕妇中高龄共289例,占总筛查人数的3.06%,其中DS、ES和NTD的阳性筛查率分别为5.4%(1/19)、0.21%(1/476)和0.32%(1/313)。确诊阳性病例19例,其中高龄10例。结论孕中期母血清三联产前筛查是检测胎儿染色体异常的有效途径,对降低出生缺陷,提高人口素质有重要意义。 Objective: To evaluate the risk of the DS, ES and NTD by detecting the concentrations of AFP, Free-βhCG and uE3 at the second-trimester maternal. Methods: Quantitative determination the concentrations of AFP, Free-βhCG and uE3 by using time-resolved fluorescence methods. The risk was calculated by Life cycle 3.2 software. Results: There were 9430 cases of pregnant women screened, advanced aging pregnancy account for 3.06%. Positive rates of Down' s syndrome (DS) , Edward's syndrome (ES) and neural tube defects (NTD) were 5.4% (1/19) , 0.21% (1/476) and 0.32% (1/313) . Confirmed positive cases were 19, 10 cases were advanced aging pregnancy. Conclusion: Second- trimester maternal serum markers triple prenatal screening is to detect fetal chromosomal abnormalities effective approach, there is great significance to reduce birth defects and improve the quality of births.
出处 《中国优生与遗传杂志》 2014年第12期52-53,106,共3页 Chinese Journal of Birth Health & Heredity
关键词 孕中期 唐氏综合症 产前筛查 Second-trimester Down syndrome Prenatal screening
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