兰州地区孕妇孕中期产前筛查结果回顾性分析

The results analysis at the second-trimester maternal prenatal screening retrospectively

目的通过检测孕妇血清中AFP,Free-βh CG和u E3的浓度,对孕中期胎儿患DS、ES和NTD的风险进行评估。方法运用时间分辨荧光法定量测定孕妇血清中AFP,Free-βh CG和u E3的浓度,采用"Life cycle 3.2"软件计算风险。结果 9430例孕妇中高龄共289例,占总筛查人数的3.06%,其中DS、ES和NTD的阳性筛查率分别为5.4%(1/19)、0.21%(1/476)和0.32%(1/313)。确诊阳性病例19例,其中高龄10例。结论孕中期母血清三联产前筛查是检测胎儿染色体异常的有效途径,对降低出生缺陷,提高人口素质有重要意义。

Objective： To evaluate the risk of the DS, ES and NTD by detecting the concentrations of AFP, Free-βhCG and uE3 at the second-trimester maternal. Methods： Quantitative determination the concentrations of AFP, Free-βhCG and uE3 by using time-resolved fluorescence methods. The risk was calculated by Life cycle 3.2 software. Results： There were 9430 cases of pregnant women screened, advanced aging pregnancy account for 3.06%. Positive rates of Down＇ s syndrome （DS） , Edward＇s syndrome （ES） and neural tube defects （NTD） were 5.4% （1/19） , 0.21% （1/476） and 0.32% （1/313） . Confirmed positive cases were 19, 10 cases were advanced aging pregnancy. Conclusion： Second- trimester maternal serum markers triple prenatal screening is to detect fetal chromosomal abnormalities effective approach, there is great significance to reduce birth defects and improve the quality of births.