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基质金属蛋白酶-11在乳腺癌中表达的研究进展 被引量：3

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摘要 在全球女性恶性肿瘤中,乳腺癌的发病率和死亡率均位居前列,对女性的生命健康威胁很大。基质金属蛋白酶-11(MMP-11)作为基质金属蛋白酶(matrix metalloproteases,MMP)家族的一种,其表达与乳腺癌发生发展的关系相当密切,被认为是影响乳腺癌预后的一个因素,但MMP-11表达在乳腺癌发生发展中的作用,仍需进一步明确。
作者 王阳 王翔 赵平
机构地区 中国医学科学院北京协和医学院肿瘤医院乳腺外科 中国医学科学院北京协和医学院肿瘤医院腹部外科
出处 《癌症进展》 2014年第5期438-442,共5页 Oncology Progress
关键词 MMP-11 乳腺癌 肿瘤侵袭 远处转移 预后因子
分类号 R737.9 [医药卫生—肿瘤]
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参考文献39

  • 1Jemal A, Bray F, Center M M, et al. Global cancer statis- tics[J], CA Cancer J Clin. 2011, 61(2): 69-90.
  • 2Femhadez-Guinea O, ,Alvarez-Cofiiio A, Eir6 N, et al. Low microvascular density at the tumor center is related to the expression of metalloproteases and their inhibitors and with the occurrence of distant metastasis in breast carcinomas[J], Int J Clin Oncol, 2013, 18(4): 629-640.
  • 3Demers M, CouiUard J, Belanger S, ct al, New roles for matrix metalloproteinases in metastasis[J]. Crit Rev Im- munol, 2005, 25(6): 493-523.
  • 4Egeblad M, Werb Z. New functions for the matrix metal- loproteinases in cancer progression[J]. Nat Rev Cancer, 2002, 2(3): 161-174.
  • 5Garcia MF, Gonzalez-Reyes S, Gonzgdez LO, et al. Com-parative study of the expression of metalloproteases and their inhibitors in different localizations within primary tumours and in metastatic lymph nodes of breast cancer [J]. Int J Exp Pathol, 2010, 91(4): 324-334.
  • 6Rundhaug JE. Matrix metalloproteinases and angiogenesis [J]. J Cell Mol Med, 2005, 9(2): 267-285.
  • 7Kalluri R. Basement membranes: structure, assembly and role in turnout angiogenesis[J]. Nat Rev Cancer, 2003, 3 (6): 422-433.
  • 8Vaupel P, Mayer A. Hypoxia and anemia: effects on tu- mor biology and treatment resistance[J]. Transfus Clin Biol, 2005, 12(1): 5-10.
  • 9Axelson H, Fredlund E, Ovenberger M, et al. Hypoxia- induced dedifferentiation of tumor cells - a mechanism behind heterogeneity and aggressiveness of solid tumors [J]. Semin Cell Dev Biol, 2005, 16(4): 554-563.
  • 10Generali D, Berruti A, Brizzi MP, et al. Hypoxia-induc- ible factor-lalpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer[J]. Clin Can- cer Res ,2006, 12(15):4562 - 4568.

二级参考文献1

  • 1P. Basset,C. Wolf,P. Chambon. Expression of the stromelysin-3 gene in fibroblastic cells of invasive carcinomas of the breast and other human tissues: a review[J] 1993,Breast Cancer Research and Treatment(3):185～193

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  • 1姜金波,李雪梅,张维东,朱民,寿楠海.血管内皮生长因子C表达和淋巴管生成与结肠癌进展及预后的关系[J].中华胃肠外科杂志,2005,8(6):516-519. 被引量：7
  • 2Bernstein WB, Dennis PA. Repositioning HIV protease in- hibitors as cancer therapeutics [J]. Current Opinion HIV & AIDS,2008,3(6) :666 - 675.
  • 3Chow WA,Jiang C,Guan M. Anti-HIV drugs for cancer therapeutics:back to the future? [J]. Lancet Oncology,2009, 10(1) :61-71.
  • 4AK Gupta, Cerniglia GJ, Rosemarie GJ, et al. HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo [J]. Cancer Research,2005, 65 (18) : 8256-8265.
  • 5Gills J J, Lopiccolo J,Tsurutani J, et al. Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum,anticancer a- gent that induces endoplasmic reticulum stress,au- tophagy,and apoptosis in vitro and in vivo [J]. Clinical Cancer Research, 2007,13 (17) : 5183-5194.
  • 6Gills J J, Lopiccolo J, Dennis PA. Nelfinavir,a new anti- cancer drug with pleiotropic effects and many paths to au- tophagy [J]. Autophagy, 2008,4 ( 1 ) : 107-109.
  • 7Lucia MB,Anu R,Handley M,et al. Exposure to HIV- protease inhibitors selects for increased expression of P- glycoprotein (ABCB1) in Kaposi's sarcoma cells [J]. British Journal of Cancer, 2011,105 (4) : 513-522.
  • 8Sgadari C,Barillari G,Toschi E,et al. HIV protease in- hibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma [J]. Nature Medicine, 2002,8 (3) : 225-232.
  • 9Esposito V,Verdina A, Manente L,et al. Amprenavir inhibits the migration in human hepatoearcinoma cell and the growth of xenografts [J]. Journal of Cellular Physiology, 2013,228(3) : 640-645.
  • 10Pore N,Gupta AK,Cerniglia GJ,et al. Nelfinavir down- regulates hypoxia-inducible factor lalpha and VEGF ex- pression and increases tumor oxygenation:implications for radiotherapy [J]. Cancer Research,2006,66 (18) :9252- 9259.

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癌症进展
2014年 第5期

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