联合检验粪便及肿瘤标志物在结、直肠癌诊治中的价值

The joint inspection value of feces and tumor markers in the diagnosis and treatment of colon and rectal cancer

目的探讨结、直肠癌患者粪便检验及血清CEA、CA199、CA242、CA724、TPA等5项肿瘤标志物的水平变化意义。方法应用化学发光法、ELISA法、粪便隐血试验等对106例结、直肠癌患者的血清和粪便进行检测,并对97例手术后2年的结、直肠癌患者血清CEA、CA199、CA242、CA724、TPA水平和隐血试验结果进行观察。结果直肠癌组血清CEA、CA199、CA242、CA724、TPA的数值明显高于未发现恶性肿瘤组(P<0.01),结、直肠癌患者手术2年后复发组与未复发组肿瘤标志物含量比较,复发组的CEA、CA199、CA242、CA724、TPA的数值明显高于未复发组(P<0.01),粪便检验结果也有明显的异常。结论联合粪便检验及5项肿瘤标志物检测对结、直肠癌的诊断和预后判断有重要的临床价值。

Objective To study the clinical significance of the detection results of feces and the changes of serum CEA,CA199,CA424,CA724 and TPA levels in patients with colon and rectal cancer. Methods Feces and serum of 106 patients with colon and rectal cancer were detected with CLIA,ELISA and fecal occult blood test. The levels of serum CEA,CA199,CA242,CA724,TPA and fecal occult blood test resluts of 97 patients who had operations before two years because of colon and rectal cancer were analyzed. Results Levels of serum CEA,CA199,CA424,CA724 and TPA in patients with rectal cancer were significantly higher than those without cancer（ P〈0. 01）. The serum tumor markers levels in the patients with colon and rectal cancer who relapsed after operation before two years were significantly higher than those who did not relapse（ P〈0. 01）.The detection results of feces had obvious abnormalities. Conclusion The joint detecton of fecal test and serum five tumor markers in patients with colon and rectal cancer would have a clinicalvalue for the diagnosis and prognosisof coloractal cancer.