舒肺贴不同贴敷时间对慢性阻塞性肺疾病稳定期生存质量的影响

Effects on Quality of Life for Stable Chronic Obstructive Pulmonary Disease by Shu-Fei Paste for Different Sticking Time

目的:分析舒肺贴不同贴敷时间对慢性阻塞性肺疾病稳定期生存质量的影响,确定最佳贴敷时间。方法:采用多中心、随机、对照的临床试验设计,将164例慢性阻塞性肺疾病稳定期患者随机分为A组和B组,其中A组82例(贴敷6-8 h);B组82例(贴敷8-12 h)。于夏季"三伏天"前的第10天、"三伏天"内的第1、10、20天,"三伏天"后的第10天各贴敷1次。研究结束后,脱落或剔除18例,本研究对符合研究要求的共146例(A组71例、B组75例)进行统计分析。结果:两组治疗后均能提高慢性阻塞性肺疾病稳定期患者的生存质量,但组间差异无统计学意义,患者贴敷6-8 h和贴敷8-12 h在治疗上均无统计学差异,但贴敷6-8 h严重大泡发生率低,安全性更好,选择6-8 h为最佳贴敷时间。结论:患者贴敷6-8 h和贴敷8-12 h在治疗上均无统计学差异,而贴敷8-12 h发生严重大泡率高,安全性较差,故舒肺贴最佳贴敷时间为6-8 h。

This study was aimed to analyze effects on quality of life （QOL） for stable chronic obstructive pulmonary disease （COPD） by Shu-Fei Paste （SFP） with different sticking time, in order to determine the optimal sticking time. A multicenter, randomized, controlled clinical trial was designed. A total of 164 stable COPD cases were randomly divided into Group A and Group B. There were 82 cases in Group A （sticking time for 6-8 h）, and 82 cases in Group B （sticking time for 8-12 h）. The paste was given 10 days before the summer “dog days”, on the 1st, 10th, and 20th day during the summer “dog days”, and 10 days after the summer “dog days”. At the end of the study, 18 cases were fallen off or removed. The 146 cases （71 cases in Group A and 75 cases in Group B）, which met the require-ments of the study, were analyzed. The results showed that both groups can improve QOL in patients with stable COPD after treatment. However, there were no statistical differences. There were no statistical differences between the sticking time for 6-8 h and sticking time for 8-12 h. However, the sticking time for 6-8 h with low incidence of severe bullous and better safety. Therefore, the best choice of sticking time was 6-8 h. It was concluded that there was no statistical differences on the treatment between the sticking time for 6-8 h and 8-12 h. However, the sticking time for 8-12 h had high rate of severe bullous and low safety. The best sticking time of SFP was 6-8 h.