成纤维细胞生长因子19(FGF-19)在肝细胞癌组织中的表达及临床意义

Expression and clinical significance of FGF-19 in hepatocellular carcinoma

目的分析成纤维细胞生长因子19(FGF-19)在肝细胞癌(HCC)以及癌旁组织中的表达及临床意义。方法选择解放军401医院2003年1月至2009年12月期间行根治切除术的HCC病例209例,应用免疫组织化学方法检测FGF-19在HCC及癌旁组织中的表达,分析FGF-19蛋白的表达与临床和病理因素的关系,采用2检验和Fisher精确检验法分析数据,Kaplan-Meier法绘制生存曲线,Cox模型分析多因素对生存的影响。结果 HCC组织中FGF-19的高表达率为66.1%(138/209),显著高于癌旁肝组织的46.9%(98/209),两组比较差异有显著统计学意义(P<0.05);FGF-19的高表达与肿瘤包膜和边界有相关性(P<0.05);FGF-19高表达组的术后生存时间明显低于FGF-19低表达组(P<0.05)。结论 FGF-19在HCC发生和进展过程中起重要作用,FGF-19的表达水平与HCC切除术后患者的生存时间密切相关,是一个潜在的预测HCC预后的分子。

Objectives To analyze the expression of fibroblast growth factor-19 （FGF-19） in hepatocellular carcinoma （HCC） and adjacent tissues, and to investigate its clinical significance. Methods A total of 209 HCC patients who had undergone radical resection operations at Hospital 401 between January 2003 and December 2009 were chosen as samples. Immunohistochemistry method was employed to examine the expression level of FGP-19 in HCC and adjacent tissues. The relationship between FGF-19 protein expressions and clinicopathologieal features was analyzed by the chi-square test or Fisher exact probability. A survival curve was drawn using the Kaplan-Meier method and the Cox model was used to analyze factors that influenced survival. Results The rate of high expression of FGF-19 was 66.1% （ 138/209 ） in HCC, which was significantly higher than 46.9% （98/209） in adjacent tissues （ P 〈 0. 05 ）. The high expression of FGF-19 was related to the tumor capsule and tumor boundary （ P 〈 0.05 ）. The overall survival in high expression of FGF-19 group was significantly lower than that in low expression group （ P 〈 0.05 ）. Conclusion FGF-19 plays an important role in the carcinogenesis and development of HCC, and a high expression of FGF-19 might be closely related to survival time of postoperative patients. FGF-19 might be a potential prognosis prediction factor for HCC.