原发性高尿酸血症与载脂蛋白E基因多态性的关联性研究

Correlation of primary hyperuricemia and apolipoprotein E gene polymorphism

目的探讨宁夏回、汉民族原发性高尿酸血症与载脂蛋白E基因多态性的关联性,为疾病的预防控制提供理论依据。方法采用病例对照方法,收集某体检机构病例组和对照组的各450例血标本及体检记录,利用连接酶反应法检测载脂蛋白E基因多态性。结果与结论病例组和对照组病例不同民族血尿酸水平差异无统计学意义。肌酐、空腹血糖、总胆固醇、甘油三酯和体质指数为高尿酸血症的危险因素。在病例组和对照组中,载脂蛋白E基因型和等位基因频率在不同民族、不同性别之间差异均无统计学意义。尚不能认为原发性高尿酸血症与载脂蛋白E基因多态性有关。

Objective To analyze the correlation of primary hyperuricemia and apolipoprotein E gene polymorphism between Hui and Han nationalities in Ningxia,and provide data for disease control and prevention.Methods Blood samples,obtained from 900 cases at some medical institutions for case-control study,were detected for gene polymorphism of apolipoprotein E by connecting the enzyme reaction.Results and Conclusion There was no statistically significant difference in the blood uric acid level in different nationality groups between the case group and the control group.Creatinine,fasting blood glucose,total cholesterol,triglycerides,and body mass index were considered risk factors of hyperuricemia.There was no statistically significant difference in apolipoprotein E genotype and allele frequency between different nationalities and genders in case group and control group.There might be no correlation of primary hyperuricemia and apolipoprotein E gene polymorphism.