口腔黏膜扁平苔藓患者应用激素治疗时Th1/Th2的应答模式及T细胞平衡相关性分析

Analysis of Th1/Th2 in the use of hormone therapy in patients with OLP when T cell response patterns and correlation

目的探讨激素对口腔黏膜扁平苔藓(OLP)患者治疗前后Th1/Th2比值及T细胞因子的表达变化及临床疗效。方法随机选取本院诊断为OLP的患者50例作为治疗组,并选取同期体检健康者50例作为对照组,治疗组患者采用地塞米松注射液治疗4周。比较治疗前、治疗后4周两组研究对象Th1/Th2比值、干扰素(IFN)-γ、IFN-α等细胞因子水平的差异,并观察治疗组的治疗效果。结果治疗组患者治疗前Th1、Th2水平分别为(79.15±7.84)、(57.77±4.66)pg/ml,治疗后Th1、Th2水平明显降低[(18.44±2.14)、(15.91±2.15)pg/ml],差异具有显著性(P<0.05);治疗组患者治疗前后Th1、Th2、Th1/Th2比值均显著高于对照组4周前及未经任何处置的4周后,差异具有显著性(P<0.05)。治疗组患者治疗前后IFN-γ、白细胞介素(IL)-2、IL-4、IL-10水平与对照组(4周后与之前数据相同)比较差异无显著性(P>0.05);治疗组患者治疗前后IFN-α、IL-6、IL-8水平均显著高于对照组(4周后与之前数据相同),差异具有显著性(P<0.05)。50例OLP患者治愈28例(56%)、有效19例(38%)、无效3例(6%)。结论 Th1/Th2比值、IFN-γ、IL-2、IL-4、IL-10与OLP病情密切相关,病情越严重,上述指标表达水平越高。

Objective To discuss therapy of Th1/Th2 in patients with OLP when T cell response patterns and correlation. Method Randomly selected 50 cases of OLP in our hospital as treatment group, 50 cases of normal as control group. Treatment group were treated with dexamethasone injection for 4 weeks. Studied differences between before and after treatment of 4 weeks, two groups of subjects of Th1/Th2 ratio, IFN-γ, IFN-α cytokine, and observed the therapeutic effect of the treatment group. Result Th1, Th2 levels of the treatment group patients before treatment were（79.15±7.84）,（57.77±4.66） pg/ml, Th1, Th2 levels were significantly lower after treatment [（18.44±2.14）,（15.91±2.15） pg/ml], the difference was significant（P〈0.05）; treatment group before and after treatment in patients with Th1, Th2 the ratio of Th1/Th2, respectively, and control group 4 weeks ago and without any disposal compared after 4 weeks, were higher than control group, the difference was significant（P〈0.05）. Treatment group patients before treatment and after treatment of IFN-γ, IL-2, IL-4, IL-10 and normal control group（4 weeks after and before the same data） no significant difference（P〉0.05）; treatment group patients before treatment and after treatment of IFN-α,IL-6, IL-8 were significantly higher than those in control group（4 weeks after the data and before the same）, the difference was significant（P〈0.05）. In 50 OLP patients and 28 cases were cured（56%）, effective 19 cases（38%）, invalid 3 cases（6%）. Conclusion The value of Th1/Th2, IFN-γ, IL-2, IL-4, IL-10 and OLP disease are closely related, the illness is more serious, the higher expression level.