黄疸型肝炎患儿采用维生素K与消旋山莨菪碱联合治疗的效果分析

Clinical analysis of jaundice hepatitis in children with vitamin K and racanisodamine tablets combination therapy

目的研究维生素K联合消旋山莨菪碱治疗小儿黄疸型肝炎临床效果,以期为临床治疗提供参考依据。方法采用随机数表法将50例黄疸型肝炎患儿分为治疗组和对照组,对照组患儿在常规黄疸型肝炎治疗基础上加用消旋山莨菪碱治疗,治疗组患儿在对照组基础上加用维生素K治疗,比较两组患儿治疗前后肝功能、凝血相关指标及疗效。结果治疗组患儿治愈19例(76.00%),显效4例(16.00%),有效2例(8.00%),无效0例(0.00%),总有效率为100.00%;对照组患儿治愈14例(56.00%),显效4例(16.00%),有效4例(16.00%),无效3例(12.00%),总有效率为88.00%,两组疗效比较差异具有显著性(P<0.05)。治疗组患儿各种症状改善率均高于对照组,但仅乏力和纳差的改善率两组比较差异具有显著性(P<0.05)。两组患儿治疗前后总胆红素、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、部分凝血活酶时间(APTT)、凝血酶原时间(PT)、血小板(PLT)水平组内比较差异具有显著性(P<0.05),治疗后治疗组患儿以上各指标改善均优于对照组,差异具有显著性(P<0.05)。结论维生素K联合消旋山莨菪碱治疗小儿黄疸型肝炎的疗效及患儿肝功能、凝血功能改善均优于常规治疗,值得临床推广应用。

Objective To study vitamin K combined with racanisodamine tablets in the treatment of infantile jaundice hepatitis clinical effect, in order to provide the reference for clinical treatment. Method 50 cases of jaundice hepatitis were randomly divided into treatment group and control group, control group based on conventional therapy jaundice hepatitis with racanisodamine tablets therapy, treatment group based on the control group with vitamin K treatment. Before and after treatment, compared two groups of related index of liver function, coagulation and curative effect. Result Treatment group 19 cases were cured（76.00%）, 4 cases were markedly effective（16.00%）, 2 cases were effective（8.00%）, 0 cases was invalid（0.00%）, the total efficiency was 100.00%; control group 14 cases were cured（56.00%）, 4 cases were markedly effective（16.00%）, 4 cases were effective（16.00%）, 3 cases was invalid（12.00%）, the total efficiency was 88.00%, the efficacy of two groups was significant（P〈0.05）. Treatment group in all kinds of symptom improvement rate were higher than that of control group, only weak and poor appetite improvement rate difference between the two groups were significant（P0.05）. Before and after treatment, total bilirubin, alanine aminotransferase（ALT）, aspartate aminotransferase（AST）, partial thromboplastin time（APTT）, prothrombin time（PT）, platelet（PLT） in the group the difference was significant（P〈0.05）. Treatment group after treatment with above indexes were better than control group, the difference was significant（P〈0.05）. Conclusion Vitamin K combined with racanisodamine tablets in the treatment of infantile jaundice hepatitis is of better curative effect and liver function, coagulation function is better than conventional treatment, worthy of clinical application.