补体因子H与年龄相关性黄斑变性的相关性研究

Research on the Correlation of Complement Factor H with Age-related Macular Degeneration

目的:探讨补体因子H与年龄相关性黄斑变性(AMD)的相关性.方法:检索分析近20年来国内外有关年龄相关性黄斑变性的病因在基因方面的研究与新进展.结果:补体因子H与年龄相关性黄斑变性的发病原因有显著相关,但存在种族差异.结论:补体因子H多态性在年龄相关性黄斑变性的发生中起着非常重要的作用,这为今后采取新的早期干预措施、寻求更为有效的治疗方法提供了新的方向.

Objective：To investigate the correlation of complement factor H with age-related macular degeneration（AMD）.Methods：The literature related with the study and new progress in genetic pathogenesis of AMD at home and abroad in lately 20 years was retrieved and analyzed.Results：Complement factor H was significantly associated with the cause of AMD,but there were racial differences.Conclusion：Complement factor H polymorphism plays a very important role in the occurrence of AMD,which provides new directions for taking new early intervention measures,and seeking more effective treatment methods in the future.