静脉药物加药口消毒及使用医用输液瓶口贴的必要性考察

Study on the Necessity for the Application of Medical Transfusion Films and Sterilization of Infusion Bottles

目的:考察静脉药物加药口消毒和使用医用输液瓶口贴的必要性。方法:在静脉药物配置中心的洁净操作环境下,向60份静脉输液中加入10 m L灭菌注射用水,模拟配制加药过程,按照《中国药典》2010版二部附录ⅪJ中细菌计数方法,对消毒组和未消毒组、医用输液瓶口贴组和未使用组的微生物污染情况进行统计分析。结果:消毒组和未消毒组在统计学意义上有显著差异(P<0.05),在使用密封消毒袋后,贴医用输液瓶口贴组和未贴组在统计学意义上没有显著差异(P>0.05)。结论:配制静脉药物时,加药口需要进行消毒,以减少加药时微生物污染的风险;使用密封消毒袋后,30 min内静脉输液不需要贴医用输液瓶口贴。

Objective: To study the necessity of sterilization of infusion bottles and application of medical transfusion films. Methods: Simulating the procedure of formulating infusion in pharmacy intravenous admixture services(PIVAS), the Colony-Forming Units(CFU) were compared between the sterilized and unsterilized groups, and between the groups with and without medical transfusion films.Results: The sterilized and unsterilized groups showed significant differences in CFU, and the groups with and without medical transfusion films showed no significant difference. Conclusion: When formulating infusion, sterilization of infusion bottles is necessary and it is unnecessary to apply medical transfusion films if the infusion is sealed by a sterilized bag and used within 30 min.