摘要
目的:制备盐酸美金刚缓释微丸,并对其体外释放度进行考察。方法:采用流化床包衣法制备盐酸美金刚载药微丸,再用Eudragit RL 30D和Eudragit RS 30D进行包衣,制成盐酸美金刚缓释微丸,并考察盐酸美金刚缓释微丸的体外释药行为。结果:体外释放度试验显示,制备的盐酸美金刚缓释微丸在24 h内平稳释放且释药完全,释药规律符合零级释药模型。结论:用本方法制备的盐酸美金刚缓释微丸具有缓释效果。
Objective： To prepare sustained-release pellets of memantine hydrochloride and investigate the in vitro drug release behavior. Methods： The drug-loaded pellets were prepared by a fluid bed coating technology,the sustained-release pellets were prepared with Eudragit RL 30 D and Eudragit RS 30 D as the coating materials,and in vitro drug release behavior of the sustained-release pellets was studied. Results： The in vitro drug release was steady and complete in 24 h,which fit a zero-order kinetics model. Conclusion：The memantine hydrochloride sustained-release pellets has the sustained-release property.
出处
《中国药师》
CAS
2015年第2期233-237,共5页
China Pharmacist
关键词
盐酸美金刚
缓释微丸
丙烯酸树脂
零级释药模型
Memantine hydrochloride
Sustained-release pellets
Polyacrylic acid resin
Zero-order kinetics model
