环孢素A与抗结核药物合用患者的药学监护

Pharmaceutical Care for Patients Treated with Cyclosporine A Combined with Anti-tuberculosis Drugs

目的:参与使用环孢素A患者的抗结核治疗实践,探讨临床药师针对药物治疗决策及药物相互作用的药学监护模式。方法:提出并细化临床问题,通过检索文献证据,对各问题进行解答并建立同类临床问题药学监护流程及模式。结果:对于使用环孢素A患者的抗结核方案应选择强有力的药物及避免药物相互作用,同时注重环孢素A血浓度监测。结论:临床药师可从治疗方案选择、药物相互作用及安全性等方面对免疫抑制患者抗结核治疗进行药学监护。

Objective： To explore the pharmaceutical care mode for drug treatment and interactions through participating in the treatment of patients using cyclosporine A combined with anti-tuberculosis（ TB） drugs. Methods： The clinical questions were proposed and refined,the literature evidence was retrieved in the electronic databases,the questions were answered and the procedure and mode of pharmaceutical care for the similar clinical problems was established. Results： For the patients with cyclosporine A treatment,strong anti-TB drugs should be chosen to ensure the effectiveness and decrease the drug interactions,and the concentration monitoring of cyclosporine A should be paid more attention. Conclusion： Clinical pharmacists can implement the pharmaceutical care for the patients with immunosuppression and TB infection through developing anti-TB regimen,avoiding the drug interactions,improving the drug safety and so on.