中西医结合治疗葡萄膜炎临床研究

Clinical Research on Treatment of Uveitis with Integrated Traditional Chinese and Western Medicine

目的:观察中西医结合治疗葡萄膜炎临床疗效及其临床优势。方法:葡萄膜炎患者1 354例随机分为两组,中西医结合组680例采用中西医结合治疗,西医组674例采用西医治疗,对两组患者的临床疗效、复发率、激素不良反应及住院天数进行随访观察。结果:随访观察6个月后,中西医结合组总体疗效明显优于西医组。中西医结合组治愈率53.08%,西医组治愈率34.08%,两组比较有显著性差异(P<0.05);中西医结合组视力治疗总有效率82.35%,西医组总有效率61.42%,两组比较有显著性差异(P<0.05);中西医结合组总复发率12.35%,西医组总复发率27.45%,两组比较有显著性差异(P<0.05);中西医结合组糖皮质激素不良反应骨质疏松、向心性肥胖、物质代谢障碍、高血压发生率分别为16.91%、13.09%、18.68%、17.94%,西医组分别为24.48%、22.55%、27.45%、31.31%,两组比较均有显著性差异(P<0.05);中西医结合组平均住院时间(13.09±3.66)d,西医组平均住院时间(16.15±4.52)d,两组比较有显著性差异(P<0.05)。结论:以"清火柔肝明目、经枢标本兼调"法为主,结合西医治疗葡萄膜炎可以明显提高治愈率和患者视力,减少复发率,提高患者的生存质量,缩短住院时间,并显著降低激素不良反应。

Objective：To observe the clinical efficacy and advantage of integrated traditional Chinese and western medicine on treating Uveitis. Methods：1 354 patients were randomly divided into 2 groups. 680 pa-tients in the integrated traditional Chinese and western（ICWM） group were treated by ICWM and 674 pa-tients in western medicine（WM） group were treated by WM. The clinical curative efficacy,relapse rate, adverse reaction induced by glucocorticoids and hospital stay of the two groups were followed up. Results：6 months after the follow-up observation,the curative efficacy of the ICWM group was obviously better than that of the WM group. The cure rate of the ICWM group was 53.68%,the WM group 34.08%. The differ-ence was statistically significant（P＜0.05）. The total effective rate of vision of the ICWM group was 82.35%, the WM group 61.42%. The difference was statistically significant（P＜0.05）. The relapse rate of the ICWM group was 12.35%,the WM group 27.45%. The difference was statistically significant（P＜0.05）. The rate of adverse reaction induced by glucocorticoids,osteoporosis,central obesity,metabolic dysfunction and hyperten-sion of the ICWM group was respectively 16.91%, 13.09%,18.68%,17.94%,the WM group 24.48%, 22.55%,27.45%,31.31%. The difference was statisti-cally significant（P＜0.05）. The average hospital stay of the ICWM group was （13.09＆#177;3.66）days,the WM group was （16.15 ＆#177;4.52）days. The difference was＆amp;nbsp;statistically significant （P＜0.05）. Conclusion：The integrated traditional Chinese and western medicine can sig-nificantly improve the eyesight and cure rate,reduce the chance of relapse,hospital stays and adverse reac-tion induced by glucocorticoids.