白细胞介素-9在胃癌前病变中的表达及意义

Expression and significance of interleukin-9 in precancerous lesions of gastric carcinoma

目的观察白细胞介素-9(IL-9)在胃良性病变、胃癌前病变及胃癌中的表达及临床意义。方法回顾性分析12例胃良性病变、38例胃癌前病变、46例胃癌患者的临床病理资料。采用免疫组化法检测上述标本中IL-9的表达水平,分析其与临床病理资料的关系。结果胃良性病变组、胃癌前病变组、胃癌组中IL-9表达差异有统计学意义(P<0.01),且胃癌前病变中IL-9表达显著高于胃癌组(P<0.01)。胃癌前病变组幽门螺旋杆菌(Hp)(+)患者IL-9表达显著高于Hp(-)患者,且组织炎症、萎缩、肠化程度越高,IL-9表达随之增加,差异具有统计学意义(P<0.05)。结论 IL-9在胃癌前病变组织中高表达并与临床病理资料密切相关,推测IL-9及其介导的免疫反应参与胃癌前病变的发生及进展。

Objective To explore the expressions and significance of interleukin-9 （IL-9） in benign gastric lesions, precancerous lesions of gastric carcinoma and gastric cacinoma. Methods Clinical pathologic materials of 12 patients with benign gastric lesions, 38 patients with precancerous lesions of gastric carcinoma and 46 patients with gastric cancer were analyzed retrospectively. Correla- tion between the expression of IL-9 and the clinical pathological materials was analyzed. Results There were significant differences in IL-9 levels among benign gastric lesions, precancerous lesions of gastric carcinoma and gastric cacinoma （P 〈 0.01 ）, and the expression of IL-9 in precancerous lesions of gastric carcinoma was significantly higher than that in gastric carcinoma （P 〈 0.01 ）. In precancer- ous lesions of gastric carcinoma, the expression of IL-9 in helicobacter pylori （Hp） （ ＋ ） patients was significantly higher than that in Hp （ - ） patients, and the expression of IL-9 increased with the in- creasing degrees of tissue inflammation, atrophy and intestinal metaplasia （P 〈 0.05 ）. Conclusion IL-9 is expressed with a high level in precancerous lesions of gastric carcinoma, and is closely related with the clinical pathological materials. It is speculated that IL-9 and its mediating immune response participate in the occurrence and progress of precancerous lesions of gastric carcinoma.