血清β人绒毛膜促性腺激素和孕酮检测在异位妊娠早期诊断中的应用价值

Value of detection of serum β-HCG and progesterone in the diagnosis of ectopic pregnancy

目的探讨血清β人绒毛膜促性腺激素(β-HCG)和孕酮(P)检测在异位妊娠(EP)早期诊断中的应用价值。方法对66例EP患者(观察组)及60例正常妊娠妇女(对照组)进行血清β-HCG和P检测并进行比较分析,同时通过后穹隆穿刺、超声等金标准分析单独检测β-HCG、P以及联合检测对EP诊断的灵敏度、特异度及准确度。结果单纯检测β-HCG对EP诊断的灵敏度、特异度、准确度优于单纯P检测,但较二者联合检测较差,差异均有统计学意义(P<0.01);EP患者血清β-HCG、P水平均显著低于正常妊娠妇女(P<0.01)。结论血清β-HCG及P联合检测在EP早期诊断中具有极高的临床价值,其灵敏度较高,准确性较好,能够在早期准确诊断EP。

Objective To discuss the clinical value of detection of serum β human chorionic gonadotrophin （β-HCG） and progesterone in the diagnosis of ectopic pregnancy （EP）. Methods Serum β-HCG and progesterone were detected in sixty-six EP patients in observation group and six- ty normal pregnancy women in control group. Besides, the methods of culdocentesis and ultrasound were applied to detect the serumβ-HCG and P, respectively. Meanwhile, serum β-HCG and P were detected at the same time to analyze the sensitivity, specificity and veracity in diagnosis of EP, and the effects of three methods above were compared. Results The sensitivity, specificity and veracity detected by β-HCG detection in the diagnosis of EP were better than those by P detec- tion, but were worse than those by combined detection of serum β-HCG and P, and there were sig- nificant differences among three methods（P 〈 0.01）. Levels of serum β-HCG and P in EP patients were significantly lower than those in the normal pregnancy women （P 〈 0.01 ）. Conclusion With the high sensitivity and veracity, the combined detection of serum β-HCG and P has a high clinical value in the diagnosis of EP, and it can make an accurate diagnosis of EP in early stage.