摘要
优选了从青蒿母液中提取青蒿酸(1)和二氢青蒿酸(2)的工艺。以1、2提取率为筛选指标,以乙醇萃取温度、碳酸氢钠溶液用量、乙醇浓度和氢氧化钠溶液浓度为考察因素,用L9(34)正交试验优选最佳提取工艺。结果 1、2提取最佳工艺参数为乙醇浓度80%,萃取温度15℃,碳酸氢钠溶液用量20 ml,氢氧化钠溶液浓度3%,1、2提取率为31.0%和30.5%,所得样品纯度大于98%。
The extraction process of artemisic acid （1） and dihydroartemisinic acid （2） from Artemisia annua mutterlauge was optimized. A L9 （34） orthogonal design was conducted, taking the extraction yields of 1 and 2 as indexes, with ethanol extraction temperature, dosage of sodium bicarbonate solution, ethanol concentration and the concentration of sodium hydroxide solution as factors. The optimum technological parameters for 1 and 2 extraction were as follows： ethanol concentration of 80%, extraction temperature of 15℃, sodium bicarbonate solution of 20 ml, and sodium hydroxide solution concentration of 3 %. The extraction yield of 1 and 2 were 31.0 % and 30.5 %, respectively, with the purities over 98 %.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2015年第2期149-151,共3页
Chinese Journal of Pharmaceuticals
关键词
青蒿酸
二氢青蒿酸
提取
artemisic acid
dihydroartemisinic acid
extraction
