难治性抑郁症认知功能的研究

The Cognitive Function in Treatment-resistant Depression

目的:探讨难治性抑郁症认知功能损害的特点。方法:对355例首发未服药的抑郁症患者在基线时评定威斯康星卡片分类测验(WCST)、连线测验(TMT)、词语流畅作业(VF)、汉诺塔(TOH)及韦氏成人智力量表(WAISRC),并予以抗抑郁药物治疗,经过两种不同作用机制抗抑郁药足量足程治疗疗效欠佳者纳入难治性抑郁组,比较难治性抑郁组与非难治性抑郁组之间认知功能的差异。结果:难治性抑郁症组TOH平均计划时间和平均执行时间均高于非难治性抑郁组,差异有统计学意义(P<0.05)。结论:与非难治性抑郁比较,难治性抑郁症患者可能执行功能受损更重。

Objective： To investigate the cognitive function in treatment-resistant depression. Methods： 355 first-epi- sode major depressive disorder patients cognitive functions were assessed by Wisconsin card sorting test（WCST）, trail marking test（TMT）, verbal fluency task（VF）, tower of Hanoi（TOH） and Wechsler adult intelligence scale revised in China（WAISRC）. They were given antidepressant treatment, the patients who have poor response to two adequate trails of different classes of antidepressants were defined as treatment-resistant depression. Cognitive functions were compared among nontreatment-resistant depression and treatment -resistant depression groups. Results： The average plan and execution time of TOH in treatment-resistant depression group were significant higher than that in non-treatment-resistant depression group（P〈0.05）. Conclusion： Compared to non-treatment-resistant depression, treatment- resistant depression patients may have worse execution function.