加减参芪地黄汤联合西药治疗气阴两虚型狼疮性肾炎的疗效观察

Efficacy of Shenqi Dihuang Decoction Combined with Western Medicine in Treatment of Qi-Yin Deficiency Type of Lupus Nephritis

目的:探讨加减参芪地黄汤联合西药治疗气阴两虚型狼疮性肾炎的疗效观察,为临床诊断治疗提供参考。方法:将本组56例气阴两虚型狼疮性肾炎患者按照随机数字表法将其随机分为对照组(n=28)和治疗组(n=28);对照组给予泼尼松片治疗,治疗组在对照组治疗基础上服用加减参芪地黄汤;两组治疗均以3个月为1个疗程,1个疗程后统计疗效。观察两组患者治疗前后狼疮活动指数、血清血管内皮细胞指数、理化检验指标(血沉、血肌酐、24 h尿蛋白)变化情况。结果:治疗组总有效率(92.86%)显著高于对照组(71.43%),且有显著性差异(P<0.05);治疗组治疗后改善狼疮活动指数、血清血管内皮细胞指数、理化检验指标(血沉、血肌酐、24 h尿蛋白)均优于对照组,且有显著性差异(P<0.05)。结论:加减参芪地黄汤联合西药治疗气阴两虚型狼疮性肾炎的疗效确切,能显著缓解临床症状及改善实验室指标,值得临床推广。

Objective： To investigate the efficacy of Shenqi Dihuang Decoction combined with western medicine in the treatment of Qi- Yin deficiency type of lupus nephritis and to provide reference for clinical diagnosis and treatment. Methods： 56 cases of patients with lupus nephritis of Qi- Yin deficiency according to random number table were randomly divided into control group（ n = 28） and treatment group（ n = 28）. The control group received prednisone tablets and the treatment group took Shenqi Dihuang Decoction on the basis of the control group. Three months was a course of treatment. Lupus activity indexes were observed before and after treatment. The serum vascular endothelial cell index,physical and chemical testing indicators（ erythrocyte sedimentation rate,serum creatinine,24 h urine protein） were observed.Results： The total effective rate（ 92. 86%） in the treatment group was significantly higher than that of the control group（ 71. 43%） and there was a significant difference（ P 0. 05）. The improvement after treatment of lupus activity index,serum vascular endothelial cell index,physical and chemical testing indicators（ erythrocyte sedimentation rate,serum creatinine,24 h urine protein） in the treatment group were better than those of the control group and there was significant difference（ P〈0. 05）. Conclusion： Modified Shenqi Dihuang Decoction combined with western medicine can significantly relieve symptoms and improve laboratory parameters of Qi- Yin deficiency type of lupus nephritis and it is worthy of promotion.