宫颈浸润癌及癌前病变与女性年龄关系的研究

Study on the Relationship between Invasive Carcinoma of Cervix,Precancerous Lesions and Women Age

目的：探讨宫颈浸润癌及癌前病变与女性年龄的关系。方法：2013年45430例已婚妇女在天津金域医学检验中心进行了宫颈浸润癌筛查。首先进行TCT检测,然后对TCT检测结果阳性病例行HC2HPV-DNA检测,两项结果为阳性者,行阴道镜及宫颈活检。对检测结果按照年龄分组进行统计分析。结果：45430例中,AS-CUS及以上者共2234例（4．92%）,而30~39岁组、40~49岁组及50~59岁组的发病率较高。2234例中HC2HPV-DNA阳性者1572例（70．37%）。20~29岁组HPV感染率最高,占该年龄段ASCUS及以上者总人数的83．52%。宫颈浸润癌及癌前病变发病率分别为0．16%及1．55%,其中40~49岁组及50~59岁组宫颈浸润癌发病率最高,均为0．28%,远高于其他年龄组,差异有统计学意义（ P〈0．05）。30~39岁组及40~49岁组的癌前病变发病率分别是1．86%和1．82%,远高于其他年龄组,差异有统计学意义（ P〈0．05）。与宫颈浸润癌高发年龄相比,癌前病变高发年龄明显提前。结论：天津市已婚妇女的癌前病变的高发年龄为30~49岁,而宫颈浸润癌的高发年龄为40~59岁。

Objective： To explore the relationship between invasive carcinoma of cervix, precancerous lesions and the age of married women. Methods：45 430 cases of married women were screened for invasive carcinoma of cervix in the Center of Tianjin KingMed Diagnostics in 2013. The screening method was described as follows：HC2HPV-DNA test was conducted for the TCT positive cases. If both were positive, the colposcopy and cervical biopsy tests were examined. The screening results were statistically analyzed according to age of women. Results： In 45 430 married women, 2 234 cases （4. 92%） were diagnosed as the ASCUS and ASCUS above in TCT test, and the incidence was relatively higher in 30-39 years, 40 -49 years and 50 -59 years old groups. Among the 2 234 cases, 1 572 cases （ 70. 37%） were detected HC2HPV-DNA positive. The HPV infection ratio was the highest in 20-29 years old group which accounted for 83. 52%of the total population of ASCUS and ASCUS above in TCT test in the same age group. The incidence of invasive carcinoma of cervix and precancerous lesions were 0. 16% and 1. 55%, respectively . 40-49 and 50-59 years old groups got the highest incidence（0. 28%） of invasive carcinoma of cervix comparing with the other groups with significant difference（P〈0. 05）. The 30-39 （1. 86%） and 40 -49 （1. 82%） years old groups had the highest incidence of precancerous lesion comparing with the other groups with significant difference（P〈0. 05）. The paroxysmal age of precancerous lesion was ob-viously earlier than that of invasive carcinoma of cervix. Conclusion：The paroxysmal age for cervical precancerous lesions was 30~49 years old, while for the invasive carcinoma of cervix was 40~59 years old in married women in Tianjin City.