微小RNA与炎性肺部疾病

MicroRNAs and inflammatory lung diseases

炎性肺部疾病（inflammatorylungdisease）包括急性呼吸窘迫综合征（ARDS）、哮喘及慢性阻塞性肺病（COPD）等，均以炎症反应为主要特征。微小RNA（miRNA）是一系列单链非编码RNA，在转录后水平调控基因表达，参与炎症、免疫及肿瘤的发生。近年来的研究已经发现了炎性肺病的miRNA的表达谱。检测miRNA有望在基因转录水平早期诊断炎性肺病，miRNA将来也可能作为炎性肺病治疗的新靶点。

Inflammatory lung diseases including acute respiratory distress syndrome （ARDS）, asthma, chronic obstructive pulmonary disease （COPD） are characterized by inflammatory response. MicroRNA （miRNA） is a series of single stranded non - coding RNA, in the regulation of gene expression at post transcription level, involved in inflammation, immunity and cancer. Recent studies have revealed that unique miRNA expression profiles exist in inflammatory lung diseases. Detection of miRNA is expected to be helpful in early diagnosis of inflammatory lung diseases. Understanding the role that miRNAs play in the modulation of gene expression leading to pulmonary inflammation is important for the development of new therapies.