摘要
腭发生是一个受多种基因调控的形态发生过程,任何异常调控都可能导致腭裂发生。目前,大量与腭发生相关的基因与细胞因子被发现,其中β-连环蛋白与无翅型小鼠乳房肿瘤病毒整合位点家族(WNT)形成WNT/β-连环蛋白信号转导通路,广泛参与腭的发生过程:WNT/β-连环蛋白与神经嵴细胞的形成和迁移分化密切相关,WNT/β-连环蛋白信号调节各面突的生长,参与头面部骨骼肌肉发育,调节腭板融合,调节腭皱的形成。本文就β-连环蛋白在腭发生的作用进行归纳与综述。
Palate is caused by various genes that regulate morphogenesis, and any abnormal regulation may lead to cleft palate. A large number of palatogenesis genes and related cytokines have been found; in these genes, beta catenin and wingless-type mouse breast tumor virus integration site family（WNT） interact to form the WNT/β-catenin signaling pathway. This pathway widely participates in the occurrence of palates. The formation, migration, and differentiation of WNT/β-catenin are closely related to those of neural crest cells. The WNT/β-catenin signaling regulates the processes involved in growth, development of head and facial skeletal muscles, adjustment of palate fusion, and regulation of palatal wrinkle formation. This paper summarized and reviewed the role of beta catenin on palatogenesis.
出处
《国际口腔医学杂志》
CAS
北大核心
2015年第2期243-247,共5页
International Journal of Stomatology
基金
四川省科技支撑计划(2011SZ0196)
