氯胺酮联合丙泊酚在小儿临床麻醉中的应用效果

The application effect of ketamine combined with propofol in pediatric anesthesia

目的评价氯胺酮联合丙泊酚在小儿临床麻醉中的应用效果。方法选取本院2012年9月～2014年9月收治的行麻醉手术患儿92例,随机分为对照组和实验组,对照组患儿采用氯胺酮麻醉,实验组患儿采用氯胺酮联合丙泊酚麻醉,观察比较两组患儿的麻醉效果、各项生命体征及术后不良反应情况。结果实验组麻醉优良率为95.74%,明显高于对照组的82.22%,差异有统计学意义（P〈0.05）。对照组麻醉成功即刻、麻醉后10 min的SBP、DBP、HR与麻醉前比较,均差异有统计学意义（P〈0.05）;实验组麻醉成功即刻的SBP与麻醉前比较,差异有统计学意义（P〈0.05）;麻醉成功即刻和麻醉后10 min两组患儿的HR、SBP、DBP差异有统计学意义（P〈0.05）。实验组患儿术后不良反应发生率明显低于对照组,差异有统计学意义（P〈0.05）。结论氯胺酮联合丙泊酚复合全麻使患儿术中生命体征平稳、麻醉效果突出、术后不良反应明显减少,是用于小儿临床麻醉较理想的组合,值得临床进一步应用。

Objective To study the effect of ketamine combined with propofol in pediatric anesthesia. Methods 92 pediatric patients who accepted anesthetization during surgery in our hospital from September 2012 to September 2014 were selected,and were randomly divided into control group and experimental group.Ketamine for anesthesia was adopted to control group,while ketamine combined with propofol for anesthesia was provided to experimental group.Anesthetic effect,vital signs,and postoperative adverse reaction in the two groups was observed and compared. Results The excellent rate of anesthetization in the experimental group was 95.74%,higher than 82.22% in the control group,the difference was significant （P〈0.05）.Compared with prior anesthetization,there was significant difference about systolic blood pressure （SBP）,diastolic blood pressure （DBP）,and heart rate （HR） at instant anesthetic success and 10 minutes after anesthetization in the control group （P〈0.OS）;In the experimental group,only SBP had significant difference at instant anesthetic success （P〈0.05）;There was significant difference about HR,SBP,and DBP between the two groups at instant anesthetic success and 10 minutes after anesthetization （P〈0.05）.The incidence of postoperative adverse reaction in the experimental group was lower than that in the control group,the difference was significant （P〈0.05）. Conclusion Ketamine combined with propofol for general anesthesia ensures stable vital signs,prominent anesthetic effect,and few postoperative adverse reactions,which is an optimal combination group in pediatric anesthesia.