老年原发性高血压患者脉压与胱抑素C的相关性

Correlation between pulse pressure and cystatin C level in aged patients with essential hypertension

目的:通过对原发性高血压病患者血清胱抑素C(Cys C)的水平测定,分析其与脉压的关系。方法:选择60例原发性高血压患者和30例正常体检者,原发性高血压患者又根据脉压(PP)水平分为PP>60mmHg组(29例)和PP≤60mmHg组(31例),采用乳胶颗粒增强免疫比浊法测定两组血清中Cys C含量,并进行统计学分析。结果:高血压患者PP>60mmHg组Cys C水平显著高于PP≤60mmHg组,且均高于正常对照组[(1.40±0.06)mg/L比(1.19±0.54)mg/L比(0.72±0.20)mg/L],P均<0.05;直线相关分析表明,高血压组Cys C与PP(r=0.325,P<0.05),SBP呈正相关(r=0.399,P<0.05),PP与SBP呈正相关(r=0.876,P<0.01)。结论:原发性高血压患者胱抑素C水平与脉压呈正相关,胱抑素C水平可作为检测高血压致肾功损伤的早期指标。

Objective：To measure serum level of cystatin C （Cys C）in patients with essential hypertension （EH）and analyze its correlation with pulse pressure （PP）.Methods：A total of 60 EH patients and 30 cases with normal physi-cal examination results were selected.According to PP level,EH patients were divided into PP〉60mmHg group （n=29）and PP≤60mmHg group （n=31）.Serum Cys C concentration was measured by latex particle-enhanced immu-noturbidimetric method in two groups,and the results were statistically analyzed.Results：Cys C level of PP 〉60mmHg group was significantly higher than that of PP≤60mmHg group,and the both groups were significantly higher than that of normal control group [（1.40±0.06）mg/L vs.（1.19±0.54）mg/L vs.（0.72±0.20）mg/L], P 〈0.05 all;linear correlation analysis indicated that Cys C level was positively correlated with PP （r =0.325,P 〈0.05）and systolic blood pressure （SBP,r = 0.399,P 〈 0.05）,and PP was positively correlated with SBP （r =0.876,P 〈0.01）in EH group.Conclusion：Cys C level is positively correlated with PP in EH patients.Cys C level can be used as an early index detecting renal function damage caused by hypertension.