多奈哌齐片联合尼莫地平治疗血管性痴呆45例的疗效

Therapeutic effect of Donepezil combined nimodipine treatment in 45 cases with vascular dementia

目的：观察多奈哌齐联合尼莫地平治疗血管性痴呆的临床疗效。方法：45例年龄在54～76岁的血管性痴呆患者被随机分为多奈哌齐＋尼莫地平组（24例）和石杉碱甲＋吡拉西坦组（21例），测定两组患者治疗前后的简明精神状态检查表（MMSE）评分和日常生活活动评分（ADL），并进行两组疗效的比较。结果：与治疗前比较，治疗后多奈哌齐＋尼莫地平组的 MMSE 评分[（15.8±6.3）分比（21.6±7.4）分]显著提高，ADL 评分[（50.3±6.4）分比（40.2±7.1）分]显著下降，石杉碱甲＋吡拉西坦组 MMSE 评分[（14.6±6.9）分比（18.5±7.2）分]显著提高，ADL 评分[（49.3±7.8）分比（43.5±8.2）分]显著下降，P 均＜0.01；但两组治疗后无显著差异（P＝0.08，0.07）。结论：多奈哌齐联合尼莫地平治疗血管性痴呆的疗效与多奈哌齐＋尼莫地平相当。

Objective：To observe the therapeutic effect of donepezil combined nimodipine on vascular dementia. Methods：A total of 45 patients with vascular dementia aging 54-76 years were randomly divided into donepezil ＋nimodipine group （n= 24）and huperzine ＋ piracetam group （n= 21）.Scores of mini-mental state examination （MMSE）and activity of daily living （ADL）were examined in two groups before and after treatment,and therapeu-tic effect was compared between two groups.Results：Compared with before treatment,after treatment,MMSE score [（15.8±6.3）scores vs.（21.6±7.4）scores]significantly rose and ADL score [（50.3±6.4）scores vs.（40.2 ±7.1）scores]significantly reduced in donepezil ＋ nimodipine group;MMSE score [（14.6±6.9）scores vs.（18.5 ±7.2）scores]significantly rose,ADL score [（49.3±7.8）scores vs.（43.5±8.2）scores]significantly reduced in huperzine ＋ piracetam group,P 〈0.01 all;but there were no significant difference between two group after treat-ment （P =0.08,0.07）.Conclusion：Therapeutic effect of donepezil combined nimodipine on vascular dementia is quite to huperzine ＋ piracetam.